家族史加抽烟：胰腺癌危险倍增
路透社纽约健康消息 最新研究发现：如果近亲中有人患胰腺癌，胰腺癌的发病机会明显增加。如果这人抽烟，危险倍增。
以前对胰腺癌相关因素的研究一般认为，年龄和吸烟是胰腺癌的主要危险因素。美国密歇根州底特律市韦恩州立大学的马里真·斯琴克博士领导的研究小组访问了247位胰腺癌患者和420位健康人，调查他们的父母或兄弟姐妹是否患有胰腺癌。结果发现，有胰腺癌近亲的人，患胰腺癌的机会增加2.5倍。不但有家庭成员患胰腺癌，而且抽烟的人，其风险更加高，这些人患胰腺癌的危险比没有这两种危险因素的人高六倍。此外，如果其亲属在60岁前患胰腺癌，风险增加到8倍多。
这项研究首次提出，近亲的胰腺癌发病年龄是吸烟者患胰腺癌的一个重要的危险因素。因此，对有胰腺癌家庭史的人来说，不抽烟至关重要。
来源：《国家癌症研究所》2001;93:640-644
Family History, Smoking Up Pancreatic Cancer Risk
NEW YORK (Reuters Health) - Having a close relative with cancer of the pancreas significantly increases an individual‘s chance of developing the disease, especially if that person smokes, researchers report.
Previous studies that looked at factors associated with pancreatic cancer have consistently identified only increasing age and smoking as major risks, according to researchers led by Dr. Maryjean Schenk from Wayne State University in Detroit, Michigan.
Schenk and her colleagues interviewed 247 patients with cancer of the pancreas and 420 people without cancer to determine whether any of their parents or siblings also had the disease.
Having a close relative with pancreatic cancer increased one‘s chance of developing the disease by 2.5 times, the authors report in the April 18th issue of the Journal of the National Cancer Institute (news - web sites).
And the risk was much higher for those individuals who not only had a family member with pancreatic cancer, but who also smoked. Their risk, the researchers found, was six times higher than that faced by people without these two risk factors. In addition, the risk grew to eightfold higher if the relative had developed pancreatic cancer before age 60.
``To our knowledge,‘‘ the authors write, ``this study is the first to suggest that the age of onset of pancreatic cancer in close relatives is an important contributing risk factor of pancreatic cancer in people who smoke.‘‘
Abstinence from smoking, Schenk told Reuters Health, is even more important for individuals in families with a history of pancreatic cancer.
SOURCE: Journal of the National Cancer Institute 2001;93:640-644, 百拇医药
以前对胰腺癌相关因素的研究一般认为，年龄和吸烟是胰腺癌的主要危险因素。美国密歇根州底特律市韦恩州立大学的马里真·斯琴克博士领导的研究小组访问了247位胰腺癌患者和420位健康人，调查他们的父母或兄弟姐妹是否患有胰腺癌。结果发现，有胰腺癌近亲的人，患胰腺癌的机会增加2.5倍。不但有家庭成员患胰腺癌，而且抽烟的人，其风险更加高，这些人患胰腺癌的危险比没有这两种危险因素的人高六倍。此外，如果其亲属在60岁前患胰腺癌，风险增加到8倍多。
这项研究首次提出，近亲的胰腺癌发病年龄是吸烟者患胰腺癌的一个重要的危险因素。因此，对有胰腺癌家庭史的人来说，不抽烟至关重要。
来源：《国家癌症研究所》2001;93:640-644
Family History, Smoking Up Pancreatic Cancer Risk
NEW YORK (Reuters Health) - Having a close relative with cancer of the pancreas significantly increases an individual‘s chance of developing the disease, especially if that person smokes, researchers report.
Previous studies that looked at factors associated with pancreatic cancer have consistently identified only increasing age and smoking as major risks, according to researchers led by Dr. Maryjean Schenk from Wayne State University in Detroit, Michigan.
Schenk and her colleagues interviewed 247 patients with cancer of the pancreas and 420 people without cancer to determine whether any of their parents or siblings also had the disease.
Having a close relative with pancreatic cancer increased one‘s chance of developing the disease by 2.5 times, the authors report in the April 18th issue of the Journal of the National Cancer Institute (news - web sites).
And the risk was much higher for those individuals who not only had a family member with pancreatic cancer, but who also smoked. Their risk, the researchers found, was six times higher than that faced by people without these two risk factors. In addition, the risk grew to eightfold higher if the relative had developed pancreatic cancer before age 60.
``To our knowledge,‘‘ the authors write, ``this study is the first to suggest that the age of onset of pancreatic cancer in close relatives is an important contributing risk factor of pancreatic cancer in people who smoke.‘‘
Abstinence from smoking, Schenk told Reuters Health, is even more important for individuals in families with a history of pancreatic cancer.
SOURCE: Journal of the National Cancer Institute 2001;93:640-644, 百拇医药