人胃癌p16/CDKN2基因蛋白质水平的异常表达
胃肿瘤;p16,CDKN2基因;异常表达,项目负责人:,Abnormalexpressionofp16,CDKN2geneatproteinlevelinhumangastriccancer,Correspondenceto,Received,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,摘要,目的,方法,结果,结论
浙江医科大学附属二院 浙江省杭州市 310009 中国项目负责人:宋震亚
Abnormal expression of p16/CDKN2 gene at protein level in human gastric cancer
Zhen-Ya Song, Rong-Zhen Xu, Ke-Da Qian, Xu-Qiu Tang, Xiao-Yin Zhao , and Min Lin
Department of Gastroenterology, 2nd Affiliated Hospital, Zhejiang Medica l University, Hangzhou 310009, China
Dr. Zhen-Ya Song, Physican in chief, having 7 papers published.
Tel: +86·571·7077272.
Correspondence to Dr. Zhen-Ya Song.
Received 18th December 1996.
Abstract
AIM To investigate for the first time p16/CDKN2 gene expression at protein level in human gastric cancer. p16/CDKN2 gene is a newly identified tumor suppresser gene and has been shown to be deleted, mutated, or rearranged in numerous human tumors. Recently, homozygous deletion of the p16/CDKN2 gene has been reported in gastric cancer cell lines with high frequency,but none in surgical specimens of gastric adenocarcinomas by Southern blot and SSCP analysis.
METHODS The expression level of p16 protein was analyzed in formalin-fixed, paraffin-embedded tissue sections from 30 cases of gastric carcinomas and 20 cases of normal gastric mucosa using a sensitive and specific immunochemical technique with protein A-gold probe. ......
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