胃肿瘤_血液供给;内皮，血管_病理学;大鼠，Wistar

MNNG诱发大鼠胃癌与间质血管的反应

http://www.100md.com 1998年2月15日《世界华人消化杂志》 1998年第2期

胃肿瘤,血液供给;内皮，血管,病理学;大鼠，Wistar,项目负责人,Correspondenceto,GastriccarcinogenesisandreactivityofmicrovesselinducedbyN-methl-N,′-nitro-N-nitrosoguanidine(MNNG)inrats,Abstract,,AIM,METHODS,RESULTS,CONCLUSION

     ¹解放军222医院消化实验室吉林省吉林市 132011

    ²吉林市第二人民医院

    高国林，男，1952-08-03生，辽宁省彰武县人，汉族. 1975年于大连军医学校毕业，现任解放军222医院消化实验室主管技师，发表医学论文50篇，获军队科技进步奖5项.

    项目负责人 高国林，132011，解放军222医院消化实验室，吉林省吉林市越山路18号.

    Correspondence to Dr. Guo-Lin Gao, Gastroenterology Laboratory, Chinese PLA 222 Hospital, 18 Yueshanlu,Jilin 132011, Jilin Province, China

    Tel. +86·432·2059626

    收稿日期 1997-09-02 接收日期 1997-09-30

    Gastric carcinogenesis and reactivity of microvessel induced by N-methl-N′-nitro-N-nitrosoguanidine (MNNG) in rats

    Guo-Lin Gao¹, Yuan Yang¹, Si-Feng Yang¹ and Jing He²

    ¹Gastroenterological Laboratory, Chinese PLA 222 Hospital, Jilin 132011, Jilin Province, China

    ²Second People＇s Hospital, Jilin City



    Abstract

    AIM To study the reactivity of microvessel in gastric carcinogenesis.

    METHODS Gastric carcinogenesis in rats was induced by topical administration of MNNG (150mg L^-1) in drinking water. Four weeks after MNNG exposure, rats were swichted to the diet containing 1, 25-dihydroxyvitamin D₃[1,25(OH)₂D₃, 2.5mg·kg^-1 and 5.0mg·kg^-1]. Animals were killed at week 8, 16,24 and 32 for immunohistochemical study of vascular endothelial cell growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) and histopathological investigation. ......

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