维生素E抗大鼠实验性肝纤维化的作用
肝硬化,预防和控制;维生素E,药理学;疾病模型，动物;大鼠，Wistar,项目负责人,Correspondenceto,EffectsofvitaminEonexperimentalhepaticfibrosisinrats,,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,摘要,目的,方法,结
第三军医大学西南医院 全军传染病中心 重庆市 400038王雅凡，女，1952-06-12生，山东莱阳市人，汉族. 1975年昆明医学院医疗系毕业，传染科副主任医师.
主要从事病毒性肝炎的临床诊治研究. 发表论文9篇.
项目负责人 王雅凡，400038，重庆市，第三军医大学西南医院全军传染病中心.
Correspondence to Dr. Ya-Fan Wang，Department of Infectious Diseases, Southwest Hospital,Third Military Medical University, Chongqing 400038, China
Tel. +86·23·67854775
收稿日期 1997-12-18
Effects of vitamin E on experimental hepatic fibrosis in rats
Ya-Fan Wang,Qi-Fen Li, Hong Wang, Qing Mao and Chun-Qing Wu
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Abstract
AIM To investigate the effects of vitamin E on hepatic fibrosis in rats induced by CCl4.
METHODS Liver fibrosis was induced in rats by subcutaneous injection of 400ml/L carbon tetrachloride oily solution for a period of nine weeks. The rats were randomly divided into treatment group (n=10), solvent (n=10) and blank control (n=10) after the liver fibrosis model was established. The treatment group was treated with vitamin E (100mg/kg) twice a week for 10-20 weeks. Serum alanine transaminase (ALT), aspartate transaminase (AST), globulin (Glb), malondialdehyde (MDA) prolidase (PLD) and hyaluronic acid (HA) were determined periodically. Histopathological examination was made in the 10th and 20th week after the administration of Vit E. ......
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