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编号:10695394
Expression and prognostic significance of P53 protein during colorectal tumorigenesis
http://www.100md.com 1998年4月15日 《世界华人消化杂志》 1998年第4期
ExpressionandprognosticsignificanceofP53proteinduringcolorectaltumorigenesis,Correspondenceto,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,INTRODUCTION,,MATERIALSANDMETHODS,Tissuesamples,Immunohistochemistry,Controls,Statistics,RESULTS,E
     1Department of Gastroenterology, General Hospital of Chinese PLA Guangzhou Command Area, Guangzhou 510010, China

    2Department of Gastroenterology, Guangzhou Sun Yat-Sen Memorial Hospital, Guangzhou 510120, China

    Dr. Xiao-Qiang Zhuang, male, born on 1963-06-03 in Guangzhou, physician-in-charge, master of gastroenterology,having 30 papers published.

    Correspondence to Xiao-Qiang Zhuang, Department of Gastroenterology,General Hospital of Chinese PLA Guangzhou Command Area, Guangzhou 510010, China

    Tel. +86·20·86664097

    Received 1997-11-20

    Abstract

    AIM To study expression and prognostic significance of P53 protein in colorectal tumors.

    METHODS
We detected the p53 expression in 45 cases of colorectal adenomas and 61 cases of colorectal carcinomas by immunohistochemical staining.

    RESULTS
The p53 positive rate was significantly higher in adenoma and carcinoma than the normals (P<0.01). In colorectal adenoma, p53 expression increased with the increase of size and dysplasia, which was higher in adenomas ≥20mm than that <10mm (77.78% vs 35.00% ......

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