Bcl-2核酶对SMMC7721细胞的促凋亡机制
肝肿瘤;Bcl-2;核酶;细胞凋亡,项目负责人,Correspondenceto,PromotionofapoptosisofSMMC7721cellsbyBcl-2ribozyme,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,摘要,目的,方法,结果,结论,主题词,0引言,1材
中国人民解放军第四军医大学 1病理学教研室 2生化教研室 陕西省西安市 710033张传山，男，1966-01-12生，天津市人，汉族. 1989年第四军医大学医疗系毕业，1994年第四军医大学病理学硕士毕业，1997年第四军医大学病理学博士，主要从事肝脏疾病的病理研究.
项目负责人 张传山，710033，陕西省西安市，中国人民解放军第四军医大学病理学教研室.
1Department of Pathology，2Department of Biochemistry, Fourth Military Medical University，Xi＇an 710033,Shaanxi Province, China
Correspondence to Chuan-Shan Zhang, Department of Pathology, Fourth Military Medical University, Xi＇an 710033,Shaanxi Province, China
Tel. 0086-29-3374541 Ext.103
收稿日期 1999-12-22 接收日期 2000-01-15
Promotion of apoptosis of SMMC7721 cells by Bcl-2 ribozyme
Chuan-Shan Zhang1, Wen-Liang Wang1, Wei-Dan Peng2, Pei-Zhen Hu1, Yu-Bo Chai2 and Fu-Cheng Ma1
Abstract
AIM To observe the effect of Bcl-2 ribozyme on SMMC 7721 cells and to investigate Bcl-2 inhibition of cellular apoptosis.
METHODS PMTr-neo (sense Bcl-2 ribozyme eucaryotic expression vector) was introduced into SMMC7221 cells by using lipofectin mediation; TUNEL and TRAP were used in combination of ELISA and IHC to determine SMMC7721/PMTr-neo proliferation and apoptosis. ......
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