猪急性肝衰模型的建立
肝功能衰竭，急性;生物人工肝;猪;动物，实验;模型,国家自然科学基金资助，,No.39570212,项目负责人,SupportedbytheNationalNaturalScienceFoundationofChina,No.39570212,Correspondenceto,Establishmentofthemodelofporcineacuteliverfailure,
中国人民解放军第一军医大学珠江医院肝胆外科 广东省广州市 510282胡还章，男，1972-02-04生，湖北省公安县人，汉族. 1994年第一军医大学临床医学本科毕业，现为第一军医大学肝胆外科研究生，主要从事生物人工肝的研究，发表论文2篇.
国家自然科学基金资助，No.39570212
项目负责人 高毅，510282，广东省广州市，中国人民解放军第一军医大学珠江医院肝胆外科.
Department of Hepatobiliary Surgery, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282,Guangdong Province, China
Supported by the National Natural Science Foundation of China, No.39570212
Correspondence to Yi Gao, Department of Hepatobiliary Surgery, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, Guangdong Province, China
Tel. 0086-20-85143556
Email. xuchopin@163.net
Received 2000-07-05 Accepted 2000-07-12
Establishment of the model of porcine acute liver failure
Huan-Zhang Hu, Xiao-Ping Xu, Yi Gao and Ji-Zhen Yang
Abstract
AIM To provide a reliable animal model for the study of treatment of acute liver failure with bioartificial liver.
METHODS Blood of eight native hybrid pigs into the livers was obstructed completely by two-phase operations. Firstly, the pigs underwent potal-right renal venous shunt. And two days later, hepatic artery, gastroduodenal artery and peri-hepatic ligaments were cut to obstruct blood flow into the liver. Acute loss of compensation of liver functions was produced and the pigs died of acute liver failure. At definite intervals (every 2h after phase Ⅱ surgery), blood was collected to assay ALT, AST, TBil Alb, Ammonia, BUN, Cr, PT and Fib and liver tissues were sampled for pathological examinations under light microscopy and electronic microscopy. Their surviving time was recorded. ......
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