乙型和丙型肝炎病毒蛋白对于细胞周期素A的调节研究
成军,刘妍, 王琳,钟彦伟, 王刚,中国人民解放军第302医院传染病研究所基因治疗研究中心, 全军病毒性肝炎防治研究重点实验室 北京市 100039
国家自然科学基金资助项目,No.C39970674, No. C03011402
项目负责人:成军, 100039, 北京市西四环中路100号,中国人民解放军第302医院传染病研究所基因治疗研究中心,全军病毒性肝炎防治研究重点实验室. cj@genetherapy.com.cn
电话:010-66933391 传真:010-63801283
收稿日期:2003-03-08 接受日期:2003-04-16
, http://www.100md.com
成军,刘妍, 王琳,钟彦伟, 王刚.乙型和丙型肝炎病毒蛋白对于细胞周期素A的调节研究.世界华人消化杂志 2003;11(8):1250-1254
Wang J, Chenivesse X, Henglein B, Brechot C. Hepatitis B virusintegration in a cyclin A gene in a hepatocellular
carcinoma. Nature 1990;343:555-557
2 Wang J, Zindy F, Chenivesse X, Lamas E, Henglein B, Brechot C.Modification of cyclin A expression by hepatitis B virus
DNA integration in a hepatocellularcarcinoma. Oncogene 1992;7:1653-1656
, 百拇医药
3 De Mitri MS, Pisi E, Brechot C, Paterlini P. Low frequency ofallelic loss in the cyclin A gene in human
hepatocellular carcinomas: a study based onPCR. Liver 1993;13:259-261
4 Zhang Y, Peng Z,Qiu G, Wang Z, Gu W. Overexpression of cyclin A in hepatocellularcarcinoma and its relationship
with HBx gene integration. ZhonghuaZhongliu Zazhi 2002;24:353-355
, 百拇医药 5 Masaki T, Shiratori Y, Rengifo W, Igarashi K, Matsumoto K, NishiokaM, Hatanaka Y, Omata M. Hepatocellular
carcinoma cell cycle: study of Long-Evanscinnamon rats. Hepatology 2000;32:711-720
6 Werling K, Szepesi A, Szentirmay Z, Schaff Z, Tulassay Z, Szalay F.Effect of hepatitis C virus on hepatocyte
proliferation and DNA ploidy in patientswith chronic hepatitis C. Z Gastroenterol 200l;38:553-558
, 百拇医药
7 Chao Y, Shih YL, Chiu JH, Chau GY, Lui WY, Yang WK, Lee SD, HuangTS. Overexpression of cyclin A but not Skp
2 correlates with the tumor relapse ofhuman hepatocellular carcinoma. Cancer Res 1998;58:985-990
8 Paterlini P, Flejou JF, De Mitri MS, Pisi E, Franco D, Brechot C.Structure and expression of the cyclin A gene in
human primary liver cancer. Correlationwith flow cytometric parameters. J Hepatol 1995;23:47-52
, http://www.100md.com
9 Romeo R, Pol S, Demeret C, Thiers V, Kremsdorf D, Cuillerier E,Berthelot P, Brechot C. Evidence of non-A, non-B,non-C infection in chronic hepatitis bypolymerase chain reaction testing for hepatitis B and C viruses. J Hepatol
1995;22:125-129
10 Faivre J, Frank-Vaillant M, Poulhe R, Mouly H, Jessus C, Brechot C,Sobczak-Thepot J. Centrosome
overduplication, increased ploidy andtransformation in cells expressing endoplasmic reticulum-associated
, http://www.100md.com
cyclin A2. Oncogene 2002;21:1493-1500
11 Tarn C, Lee S, Hu Y, Ashendel C, Andrisani OM. Hepatitis B virus Xprotein differentially activates RAS-RAF-MAPK and
JNK pathways in X-transforming versusnon-transforming AML12 hepatocytes. J Biol Chem 2001;276:34671-34680
12 Bouchard M, Giannakopoulos S, Wang EH, Tanese N, Schneider RJ.Hepatitis B virus HBx protein activation of
, 百拇医药
cyclin A-cyclin-dependent kinase 2complexes and G1 transit via a Src kinase pathway. J Virol 2001;75:4247-4257
13 Berasain C, Patil D, Perara E, Huang SM, Mouly H, Brechot C.Oncogenic activation of a human cyclin A2 targeted to
the endoplasmic reticulum upon hepatitis Bvirus genome insertion. Oncogene 1998;16:1277-1288
14 Haviv I, Matza Y, Shaul Y. pX, the HBV-encoded coactivator,suppresses the phenotypes of TBP and TAFII250
, 百拇医药
mutants. Genes Dev 1998;12:1217-1226
15 Wolowiec D, Ffrench M. Cyclins A and B: redundancy and specificity.Pathol Biol (Paris) 1993;41:547-553
16 Strassburg CP, Alex B, Zindy F, Gerken G, Luttig B, Meyer zumBuschenfelde KH, Brechot C, Manns MP. Identification
of cyclin A as a molecular target ofantinuclear antibodies (ANA) in hepatic and non-hepatic autoimmunediseases.
, http://www.100md.com
J Hepatol 1996;25:859-866
17 Blanc P, Etienne H, Daujat M, Fabre I, Zindy F, Domergue J, AstreC, Saint Aubert B, Michel H, Maurel P.
Mitotic responsiveness of cultured adulthuman hepatocytes to epidermal growth factor, transforming growthfactor
alpha, and human serum. Gastroenterology 1992;102:1340-1350
18 Ilyin GP, Langouet S, Rissel M, Delcros JG, Guillouzo A,Guguen-Guillouzo C. Ribavirin inhibits protein synthesis and
, 百拇医药
cell proliferation induced by mitogenicfactors in primary human and rat hepatocytes. Hepatology 1998;27:1687-1694
19 Lee S, Tarn C, Wang WH, Chen S, Hullinger RL, Andrisani OM.Hepatitis B virus X protein differentially regulates cell
cycle progression in X-transforming versusnontransforming hepatocyte (AML12) cell lines. J Biol Chem
2002;277:8730-8740
20 Ozturk M. Genetic aspects of hepatocellular carcinogenesis. SeminLiver Dis 1999;19:235-242
, http://www.100md.com
21 D'Errico A, Fiorentino M, Ponzetto A, Daikuhara Y, Tsubouchi H,Brechot C, Scoazec JY, Grigioni WF. Liver
hepatocyte growth factor does not alwayscorrelate with hepatocellular proliferation in human liver lesions:
its specific receptor c-met does.Hepatology 1996;24:60-64
22 Brechot C. Oncogenic activation of cyclin A. Curr Opin Genet Dev 1993;3:11-18
23 Wolowiec D, Ffrench M. Mitotic cyclins-new possibilities forexamining mechanisms of neoplasm growth. Postepy Hig
, 百拇医药
Med Dosw 1993;47:183-191
24 Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G. Cyclin A isrequired at two points in the human cell cycle.
EMBO J 1992;11:961-971
25 Blanquet V, Wang JA, Chenivesse X, Henglein B, Garreau F, BrechotC, Turleau C. Assignment of a human cyclin
A gene to 4q26-q27. Genomics 1990;8:595-597, 百拇医药( 成 军, 刘 妍, 王 琳, 钟彦伟, 王 刚)
国家自然科学基金资助项目,No.C39970674, No. C03011402
项目负责人:成军, 100039, 北京市西四环中路100号,中国人民解放军第302医院传染病研究所基因治疗研究中心,全军病毒性肝炎防治研究重点实验室. cj@genetherapy.com.cn
电话:010-66933391 传真:010-63801283
收稿日期:2003-03-08 接受日期:2003-04-16
, http://www.100md.com
成军,刘妍, 王琳,钟彦伟, 王刚.乙型和丙型肝炎病毒蛋白对于细胞周期素A的调节研究.世界华人消化杂志 2003;11(8):1250-1254
Wang J, Chenivesse X, Henglein B, Brechot C. Hepatitis B virusintegration in a cyclin A gene in a hepatocellular
carcinoma. Nature 1990;343:555-557
2 Wang J, Zindy F, Chenivesse X, Lamas E, Henglein B, Brechot C.Modification of cyclin A expression by hepatitis B virus
DNA integration in a hepatocellularcarcinoma. Oncogene 1992;7:1653-1656
, 百拇医药
3 De Mitri MS, Pisi E, Brechot C, Paterlini P. Low frequency ofallelic loss in the cyclin A gene in human
hepatocellular carcinomas: a study based onPCR. Liver 1993;13:259-261
4 Zhang Y, Peng Z,Qiu G, Wang Z, Gu W. Overexpression of cyclin A in hepatocellularcarcinoma and its relationship
with HBx gene integration. ZhonghuaZhongliu Zazhi 2002;24:353-355
, 百拇医药 5 Masaki T, Shiratori Y, Rengifo W, Igarashi K, Matsumoto K, NishiokaM, Hatanaka Y, Omata M. Hepatocellular
carcinoma cell cycle: study of Long-Evanscinnamon rats. Hepatology 2000;32:711-720
6 Werling K, Szepesi A, Szentirmay Z, Schaff Z, Tulassay Z, Szalay F.Effect of hepatitis C virus on hepatocyte
proliferation and DNA ploidy in patientswith chronic hepatitis C. Z Gastroenterol 200l;38:553-558
, 百拇医药
7 Chao Y, Shih YL, Chiu JH, Chau GY, Lui WY, Yang WK, Lee SD, HuangTS. Overexpression of cyclin A but not Skp
2 correlates with the tumor relapse ofhuman hepatocellular carcinoma. Cancer Res 1998;58:985-990
8 Paterlini P, Flejou JF, De Mitri MS, Pisi E, Franco D, Brechot C.Structure and expression of the cyclin A gene in
human primary liver cancer. Correlationwith flow cytometric parameters. J Hepatol 1995;23:47-52
, http://www.100md.com
9 Romeo R, Pol S, Demeret C, Thiers V, Kremsdorf D, Cuillerier E,Berthelot P, Brechot C. Evidence of non-A, non-B,non-C infection in chronic hepatitis bypolymerase chain reaction testing for hepatitis B and C viruses. J Hepatol
1995;22:125-129
10 Faivre J, Frank-Vaillant M, Poulhe R, Mouly H, Jessus C, Brechot C,Sobczak-Thepot J. Centrosome
overduplication, increased ploidy andtransformation in cells expressing endoplasmic reticulum-associated
, http://www.100md.com
cyclin A2. Oncogene 2002;21:1493-1500
11 Tarn C, Lee S, Hu Y, Ashendel C, Andrisani OM. Hepatitis B virus Xprotein differentially activates RAS-RAF-MAPK and
JNK pathways in X-transforming versusnon-transforming AML12 hepatocytes. J Biol Chem 2001;276:34671-34680
12 Bouchard M, Giannakopoulos S, Wang EH, Tanese N, Schneider RJ.Hepatitis B virus HBx protein activation of
, 百拇医药
cyclin A-cyclin-dependent kinase 2complexes and G1 transit via a Src kinase pathway. J Virol 2001;75:4247-4257
13 Berasain C, Patil D, Perara E, Huang SM, Mouly H, Brechot C.Oncogenic activation of a human cyclin A2 targeted to
the endoplasmic reticulum upon hepatitis Bvirus genome insertion. Oncogene 1998;16:1277-1288
14 Haviv I, Matza Y, Shaul Y. pX, the HBV-encoded coactivator,suppresses the phenotypes of TBP and TAFII250
, 百拇医药
mutants. Genes Dev 1998;12:1217-1226
15 Wolowiec D, Ffrench M. Cyclins A and B: redundancy and specificity.Pathol Biol (Paris) 1993;41:547-553
16 Strassburg CP, Alex B, Zindy F, Gerken G, Luttig B, Meyer zumBuschenfelde KH, Brechot C, Manns MP. Identification
of cyclin A as a molecular target ofantinuclear antibodies (ANA) in hepatic and non-hepatic autoimmunediseases.
, http://www.100md.com
J Hepatol 1996;25:859-866
17 Blanc P, Etienne H, Daujat M, Fabre I, Zindy F, Domergue J, AstreC, Saint Aubert B, Michel H, Maurel P.
Mitotic responsiveness of cultured adulthuman hepatocytes to epidermal growth factor, transforming growthfactor
alpha, and human serum. Gastroenterology 1992;102:1340-1350
18 Ilyin GP, Langouet S, Rissel M, Delcros JG, Guillouzo A,Guguen-Guillouzo C. Ribavirin inhibits protein synthesis and
, 百拇医药
cell proliferation induced by mitogenicfactors in primary human and rat hepatocytes. Hepatology 1998;27:1687-1694
19 Lee S, Tarn C, Wang WH, Chen S, Hullinger RL, Andrisani OM.Hepatitis B virus X protein differentially regulates cell
cycle progression in X-transforming versusnontransforming hepatocyte (AML12) cell lines. J Biol Chem
2002;277:8730-8740
20 Ozturk M. Genetic aspects of hepatocellular carcinogenesis. SeminLiver Dis 1999;19:235-242
, http://www.100md.com
21 D'Errico A, Fiorentino M, Ponzetto A, Daikuhara Y, Tsubouchi H,Brechot C, Scoazec JY, Grigioni WF. Liver
hepatocyte growth factor does not alwayscorrelate with hepatocellular proliferation in human liver lesions:
its specific receptor c-met does.Hepatology 1996;24:60-64
22 Brechot C. Oncogenic activation of cyclin A. Curr Opin Genet Dev 1993;3:11-18
23 Wolowiec D, Ffrench M. Mitotic cyclins-new possibilities forexamining mechanisms of neoplasm growth. Postepy Hig
, 百拇医药
Med Dosw 1993;47:183-191
24 Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G. Cyclin A isrequired at two points in the human cell cycle.
EMBO J 1992;11:961-971
25 Blanquet V, Wang JA, Chenivesse X, Henglein B, Garreau F, BrechotC, Turleau C. Assignment of a human cyclin
A gene to 4q26-q27. Genomics 1990;8:595-597, 百拇医药( 成 军, 刘 妍, 王 琳, 钟彦伟, 王 刚)
