长春新碱诱导人胃癌耐药细胞表达P-糖蛋白由核因子-kB活化调控
王维,罗和生,项目负责人,:,InvolvementofNF-kappaBactivationinP-glycoproteinexpressioninvincristine-resistanthumangastriccancercells,Correspondenceto:,Abstract,摘要,目的,方法,结果,结论,0,引言,1,材料和
王维,罗和生, 武汉大学人民医院消化内科 湖北省武汉市 430060王维,女, 1976-02-14生,湖北省武汉市人,汉族. 武汉大学人民医院消化内科博士生.
项目负责人:罗和生,430060, 湖北省武汉市,武汉大学人民医院消化内科. luotang@public.wh.hb.cn
电话:027-88041911-2134
收稿日期:2003-09-18 接受日期:2003-10-27
Involvement of NF-kappa B activation in P-glycoprotein expression invincristine-resistant human gastric cancer cells
Wei Wang, He-Sheng Luo
Wei Wang, He-Sheng Luo, Department of Gastroenterology, RenminHospital of Wuhan University, Wuhan 430060, Hubei Province, China
Correspondence to: Dr. He-Sheng Luo, Department of Gastroenterology,Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China. luotang@public.wh.hb.cn
Received: 2003-09-18 Accepted:2003-10-27
AbstractAIM: To investigate the effect of vincristine on activation of nuclearfactor-kappa B (NF-kB)and expression of p-glycoprotein (P-gp) in vincristine-resistant humangastric cancer SGC7901 cells (SGC7901/VCR) and the parent sensitive clone(SGC7901).
METHODS:NF-kB-DNAbinding activity was determined by electrophoretic mobility shift assay (EMSA).Levels of inhibitory kB(IkB-a)and P-gp were measured by cellular-ELISA. And immunocytochemistry was usedto detect the translocation of P65. ......
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