【摘要】 目的 探讨镉对大鼠胚胎的毒性效应及可能机制，为镉接触人群对子代影响提供动物实验依据。方法 雌雄性大鼠同笼交配，将获取的孕鼠随机分为对照组、低镉组、中镉组、高镉组。分别在孕第7、10、13天经腹腔注射氯化镉溶液，妊娠21天，剖宫取胎鼠，并取出胎鼠的肝、脑组织测定其镉锌含量、T-AOC、Pro、5-HT等的含量，另取肝、脑和胸腺组织病检。结果 (1)高镉组未见存活胎鼠;(2)孕鼠染毒后胎鼠肝组织镉含量增加并伴组织损伤，而脑组织镉与锌含量呈负相关;(3)染镉组胎鼠脑组织5-HT、T-AOC较对照组下降。结论 (1)镉可透过胎盘屏障和部分透过血脑屏障，高镉可致受精卵不能发育为胚胎;(2)母鼠染镉可致胎鼠脑组织5-HT合成减少，抗氧化能力减弱;这些改变与锌的含量和分布改变有关。

    关键词 镉 大鼠 胚胎毒性 锌

    Study on embryonic damage induced by cadmium in rat Shi Xiuquan，

    Wang Keyue，Li Hong，et al.

    Zunyi Medical College，Zunyi，Guizhou563003.

    【Abstract】 Objective To explore the toxicity and mechanism of rat’s embryoes which induced by cadmium.Methods Female and male rats were put to copulate to collect pregnant rats and then they were randomly divided inˉto four groups.Different doses of CdCl 2 were given to pregnant dams intraperitoneally at the7th ......