【摘要】 目的 研究CD34(Cluster of differentiation，白细胞分化抗原)蛋白在垂体腺瘤中表达，探讨抗CD34单抗标记的微血管密度(Mi-crovascular Density，MVD)与垂体腺瘤分级的关系及其临床意义。方法 采用免疫组化SP法对41例垂体腺瘤组织及5例正常垂体组织中CD34的表达进行检测。结果 41例垂体腺瘤组织中平均MVD为20.9±7.98，5例正常垂体组织的平均MVD为12.20±2.39，二者差异具有显著性(P<0.05)。其中平均MVD值在23例侵蚀型垂体腺瘤组(Ⅲ～Ⅴ级)为26.96±4.83，在18例封闭型垂体腺瘤组(Ⅰ～Ⅱ级)为13.17±2.57，侵蚀型垂体腺瘤组的平均MVD与封闭型垂体腺瘤组和正常垂体组织组之间的差异均有显著性(P<0.01)，而封闭型垂体腺瘤组和正常垂体组织组平均MVD的之间差异无显著性(P>0.05)。结论 抗CD34单抗标记的肿瘤微血管密度与垂体腺瘤的临床分级密切相关，是反映垂体腺瘤侵袭性行为的有用指标。

    关键词 垂体腺瘤 血管生成 微血管密度

    Detection of microvascular density in pituitary adenoma

    tissues and its clinical significance

    Yang Jile，Wu Weiping.

    Department of Neurology，the No.273Hospital，PLA，Kuerle，Xinjiang841000.

    【Abstract】 Objective To investigate the expression of CD34in pituitary adenoma tissues and explore the reˉlationship between microvascular density(MVD)and clinicobilogical behavior in human pituitary adenoma.Methods The expression of CD34in41cases of human pituitary adenoma and5cases of normal pituitary tissueswere inestigatˉed with immunohistochemistry.Results The MVD were20.9±7.98and12.20±2.39in the pituitary adenoma tisˉsues and normal pituitary tissues ......