【摘要】 目的 比较剂量相同的舒降之(辛伐他汀)隔日服药与每日服药对高脂血症的治疗作用。方法 随机、前瞻性、非双盲比较73例低密度脂蛋白胆固醇(LDL-C)≥4.1mmol/L的患者，抽血测空腹及服药后6周与12周的LDL-C、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)，随机分隔日服药组与每日服药组，剂量均为20mg，同时行肝功能、肌酐等多项实验室检查。结果 86例入选，73例完成试验。两组在降低LDL-C、TC、TG及升高HDL-C与试验前降低的百分率无统计学差异。两组副作用比较差异亦无显著性。结论 舒降之隔日用药与每日用药在治疗高脂蛋白血症患者疗效与安全性相近似，且降低医疗费用，并提高了患者服药的顺从性。

    Efficacy of alternate-day dose versus daily dosing of simvastatin in patients with hyper cholesterolemia

    Huang Jianming，Yu Zehong，Chen Linxiang，et al. Heshan People’s Hospital.Heshan，Guangdong529700.

    【Abstract】 Objective To compare the efficacy of alternate-day simvastatin administration with that of daily therapy of same dose.Methods This was a randomized prospective，nonblinded clinical trial73patients with lowdenˉsity Lipoprotein cholesterol(LDL-C)≥4.1mmol/L were enrolled.Baseline fasting and ofter6weeks ......