【摘要】 目的 了解输血相关病毒(TTV)在我国母婴传播的可能及分子病毒学依据。方法 应用PCR调查我院2002年1～12月间住院的174例产妇及其新生儿的TTV感染情况，用克隆后序列分析测定两对母婴同时阳性者TTV基因序列。结果 在174例产妇中有24例用半巢式PCR可检测出TTV，检出率为13.8%，其中4例产妇与新生儿同时阳性(4.6%);配对比较两对母婴TTV序列片段(1915～2185核苷酸片段)同源性均为100%。结论 TTV在我国可通过母婴传播的途径感染，此结果丰富了对TTV传播途径的认识。TTV对胎儿的危害及新生儿生长发育的影响值得进一步研究。

    TTV transmission from mother to infant

    Chen Yong，Du Jianping

    Dept.of Blood Transfusion of He-Ze Municipal Hospital，Shandong274000.

    【Abstract】 Objective Mother to infant transmission of a novel virus named TT virus was investigated in sera from174mothers and their infants.24cases(13.8%)of the mothers were found to harbor TTV in serum by a semˉinested PCR using a set of primers from conserved region in the TTV genome.Among them there were4infants and their born mothers possessed positive sequences simultaneously(4.6%).We carried out cloning sequencing of the amˉplicons with BAI310automated sequencer using primer T7or SP6as sequencing primers.Homology analysis was done with sequences between positions1915and2185of the published TTV genome.Analysis of TTV sequences from the infected mother and their infected child confirmed a genetic link between the virus of the mother and the infected child.This study indicates there is a possibility of mother to infant transmission of TTV in China. ......