当前位置: 首页 > 期刊 > 《循环学杂志》 > 2003年第1期 > 正文
编号:10585945
Intravascular Ultrasound Guidance Improves Angiographic and Clinical Outcome of Stent Implantation for Long Coronary Artery Stenoses
http://www.100md.com 《循环学杂志》2003年第1期
     From the Department of Cardiology (P.V.O., M.J.S., J.W.J., E.E.v.d.W.), Leiden University Medical Center, Leiden, the Netherlands; Cardiovascular Research Foundation (G.S.M.), New York, NY; and Department of Medical Statistics (A.H.Z.), Academic Medical Center, Amsterdam, the Netherlands.w'(y\1, 百拇医药

    Abstractw'(y\1, 百拇医药

    Background— Long coronary lesions treated with stents have a poor outcome. This study compared the 6-month outcome of stent implantation for long lesions in patients randomized to intravascular ultrasound (IVUS; n=73) or angiographic guidance (n=71).w'(y\1, 百拇医药

    Methods and Results— Stenoses >20 mm in length and a reference diameter that permitted a stent diameter 3 mm were eligible. Primary end points were 6-month minimal lumen diameter (MLD) and the combined end point of death, myocardial infarction, and target-lesion revascularization (TLR). Baseline clinical and angiographic data were comparable in both groups. At 6 months, MLD in the IVUS group (1.82±0.53 mm) was larger than in the angiography group (1.51±0.71 mm; P=0.042). TLR and combined end-point rates at 6 months were 4% (n=3) and 6% (n=4) in the IVUS group and 14% (n=10) and 20% (n=14) in the angiography group, respectively (P=0.037 for TLR and P=0.01 for combined events). Restenosis (>50% diameter stenosis) was found in 23% of the IVUS group and 45% of the angiography group (P=0.008). At 12 months, TLR and the combined end point occurred in 10% (n=7) and 12% (n=9) of the IVUS group and 23% (n=17) and 27% (n=19) of the angiography group (P=0.018 and P=0.026), respectively.

    Conclusions— Angiographic and clinical outcome up to 12 months after long stent placement guided by IVUS is superior to guidance by angiography.c&8n, 百拇医药

    Key Words: stents • restenosis • ultrasonicsc&8n, 百拇医药

    Introductionc&8n, 百拇医药

    Patients with long coronary artery stenoses represent a difficult subset in the population considered for percutaneous intervention.1–3 In contrast to shorter lesions, stent placement for longer stenoses is generally avoided because of high restenosis rates.4–6 Final dimensions after stenting are a strong predictor of outcome.7–10 Because lumen and stent dimensions can be accurately determined by intravascular ultrasound (IVUS), guidance of stenting by IVUS has been proposed as a method to reduce restenosis rates.11 However, randomized studies investigating this strategy have yielded inconsistent results.12–17 We hypothesized that the potential advantages of IVUS guidance would be most apparent in complex lesions, such as long stenoses. In this report, we compared the clinical and angiographic outcome after stenting of long coronary artery stenoses with randomization to angiographic or IVUS guidance of the intervention. The acronym TULIP refers to "Thrombocyte activity evaluation and effects of Ultrasound guidance in Long Intracoronary stent Placement," because platelet activity was evaluated in a subgroup of patients.

    Methodsmr{*%, 百拇医药

    Patientsmr{*%, 百拇医药

    Consecutive patients referred for elective percutaneous intervention were included. Patients were eligible if they had a de novo, nonostial stenosis 20 mm length in a native coronary artery with a reference diameter that permitted implantation of 3-mm stents without involvement of significant side branches (diameter 2.0 mm). Patients with recent (<2 weeks) myocardial infarction (MI), total occlusion, and/or contraindications for combined antiplatelet therapy with ticlopidine and acetylsalicylic acid were excluded. The institutional ethics committee approved the study protocol. Written informed consent was obtained from all patients. Randomization to IVUS or angiographic guidance was done just before the procedure.mr{*%, 百拇医药

    Stent Implantation, Angiography, and IVUSmr{*%, 百拇医药

    All patients received 7500 U of heparin twice during the procedure and 240 mg of acetylsalicylic acid plus 500 mg of ticlopidine at the end of the procedure, followed by 250 mg/d of ticlopidine for 4 weeks and 80 mg/d of acetylsalicylic acid indefinitely. In this study, AVE GFX-XL (Medtronic/AVE) stents were used exclusively. If more than 1 stent was required, additional AVE GFX stents were used. Stent size and length were selected based on online quantitative angiographic (QCA) measurements. Stent deployment with 9 atm was mandatory and, if necessary, supplemented by higher-pressure dilations to achieve the following criteria for angiographically successful stent placement: (1) complete coverage of the stenotic segment; (2) angiographic residual diameter stenosis <30%; and (3) absence of angiographically visible dissections.

    In patients assigned to IVUS-guided stenting, final balloon diameter and additional stent size were determined by ultrasound measurements. Balloon dilations were performed until the following IVUS criteria were fulfilled: (1) complete stent apposition; (2) in-stent minimal lumen diameter (MLD) 80% of the mean of proximal and distal reference diameters; and (3) in-stent minimal lumen area (MLA) greater than or equal to distal reference lumen area. We used the Endosonics/Jomed IVUS system, which allows digital storage of pullback sequences. Automated pullbacks at 1 mm/s were performed before intervention and repeated after stenting and after every dilation until all IVUS criteria were fulfilled. Trained catheterization laboratory personnel performed online IVUS measurements, according to previously described methods.16h&ahdq, 百拇医药

    Each angiogram or ultrasound sequence was preceded by 200 to 300 µg of intracoronary nitroglycerin. Three angiograms in 2 orthogonal projections were obtained in each patient: before intervention, immediately after the intervention, and at 6-month follow-up. Angiograms were analyzed with validated QCA systems (CMS 4.1; Medis)17 by an independent core laboratory (HeartCore, Leiden, the Netherlands) that was blinded as to IVUS assignment.

    Follow-Up and End Pointseo, 百拇医药

    Clinical follow-up included an interview, physical examination, blood chemistry, electrocardiography, and exercise testing at 1 and 6 months, as well as a telephone interview at 12 months. Repeat angiography was scheduled at 6 months. Angiography performed at 3 months was only used as follow-up if restenosis was present; otherwise, it was repeated at 6 months. Angiographic MLD at 6 months and the combined event rate of cardiac death, MI, and ischemia-driven target-lesion revascularization (TLR) within 6 months were the angiographic and clinical primary end points, respectively. Secondary end points were (1) angiographic and procedural success, (2) angiographic restenosis (>50% diameter stenosis) and percent diameter stenosis at 6 months, and (3) combined event frequency at 12 months. Angiographic success was defined as a residual diameter stenosis by core laboratory analysis <30% after successful stent implantation. Procedural success was defined as angiographic success without in-hospital death, MI, or emergency bypass surgery. Cardiac death included all fatal events unless a cardiac cause was unequivocally ruled out. MI was defined as new Q waves or an elevation of creatine kinase >2 times normal with corresponding changes in myocardial isoenzyme levels. Ischemia-driven TLR was indicated if there was angiographic restenosis and either angina or a positive exercise test.18

    Sample Size Calculation and Statisticsm, 百拇医药

    Sample size calculation was based on the presumption that a difference 0.25 mm in MLD at 6 months was clinically relevant. With a standard deviation of 0.5 mm, a sample size of 64 patients per group was calculated to achieve a power of 0.8 at a significance level of 0.05. Assuming 10% to 15% loss to follow-up, 75 patients per group were to be included. Analysis was done according to the intention-to-treat principle. Continuous variables were compared with the Student’s t test, and the 2 statistic was used for categorical data. Multivariate analysis was done by the stepwise logistic regression method or Cox regression analysis where applicable, and log rank testing was used for comparison of the Kaplan-Meier survival curves (SPSS version 10.0.7).m, 百拇医药

    Resultsm, 百拇医药

    Patient Characteristicsm, 百拇医药

    From June 1998 to January 2001, 150 patients were enrolled, of whom 74 were randomized to IVUS-guided stenting and 76 to angiographic guidance. Just before the intervention, 4 patients were secondarily excluded and referred for bypass surgery because of disease progression (1 patient in each group had previously unrecognized left main stenoses, and 2 patients assigned to angiographic guidance had progression to total occlusion). Two patients randomized to angiographic guidance refused the allocated strategy and were excluded from intention-to-treat analysis. Angiography at 6 months was available in 125 (87%) of 144 patients (64 [88%] of 73 IVUS-guided patients and 61 [86%] of 71 patients in the angiography group). In both groups, the stent could not be delivered to the target in 1 patient. In the angiography group, 2 patients did not receive stents after predilation (operator choice). In the IVUS group, coronary rupture after predilation necessitated acute bypass surgery in 1 patient. Ultimately, 71 patients in the IVUS group (97%) and 68 in the angiography group (96%) received the assigned treatment (P=NS). At 6 months, clinical follow-up was available for 144 patients (100%), and at 12 months, 70 IVUS-guided patients (96%) and 68 patients in the angiography group (96%) were interviewed Baseline clinical characteristics were similar in both groups Because lesion lengths >20 mm were required for inclusion, by definition all lesions were type C.19

    fig.ommittedm9-{, 百拇医药

     Trial patient inclusion and follow-up. Angio indicates angiographic guidance. Secondary exclusion was necessary for previously unrecognized significant left main stenosis (1 patient in both groups), progression to total occlusion (2 Angio patients), and refusal of the allocated stenting strategy (2 Angio patients).m9-{, 百拇医药

    fig.ommittedm9-{, 百拇医药

     Baseline Characteristicsm9-{, 百拇医药

    Procedural Characteristicsm9-{, 百拇医药

    There was a significant increase in stent length and number of stents associated with IVUS guidance The final balloon was larger in the IVUS group, whereas maximal inflation pressures were equivalent. Angiographic success was achieved in 97% of patients in both groups (P=NS). Abciximab was used more often in the IVUS group because of flow-limiting thrombus or side-branch dissectionsm9-{, 百拇医药

    fig.ommittedm9-{, 百拇医药

     Procedural Data and QCAm9-{, 百拇医药

    Online IVUS measurements at the end of the procedure showed an MLA of 6.0±3.3 mm2, with proximal and distal reference areas of 8.8±3.3 and 5.9±2.5 mm2, respectively; the MLD was 2.8±0.3 mm, with proximal and distal reference diameters of 3.3±0.4 and 2.7±0.4 mm, respectively. All criteria for optimal stent placement were achieved in 65 patients (89%). In the other 8 patients (10%), final in-stent MLA remained smaller than the distal reference lumen despite a balloon-to-vessel ratio up to 1.3 and/or high-pressure inflations.

    Angiographic Analysis(, 百拇医药

    QCA showed that the preintervention lesion parameters were equivalent. Final and follow-up MLDs in the IVUS group were significantly larger than in the angiography group ). Angiographic restenosis occurred in 15 (23%) of 64 IVUS-guided patients and in 28 (46%) of 61 patients in the angiography group (P=0.0082). depicts the cumulative frequency curves of the MLD before stent placement, after stent placement, and at 6-month follow up for both groups.(, 百拇医药

    fig.ommitted(, 百拇医药

     Cumulative distribution of MLD. Pre indicates before intervention; Post, after intervention; and FU, follow-up.(, 百拇医药

    Angiographic 6-month MLD in diabetics was smaller than in nondiabetics (1.69±0.6 versus 1.4±0.5 mm; P=0.044). Statin use was associated with a significantly larger 6-month MLD (1.8±0.6 versus 1.4±0.6 mm; P=0.003). No other medication, including abciximab, had a significant effect on follow-up MLD.(, 百拇医药

    Significant correlations could be demonstrated between follow-up MLD and initial reference diameter (r=0.56, P<0.001), initial MLD (r=0.20, P=0.001), final balloon size (r=0.42, P<0.001), and postprocedural MLD (r=0.56, P<0.001). However, follow-up MLD had no relationship with lesion length, stent length, or number of stents. Because final balloon size, final MLD, stent length, and the number of stents were consequences of IVUS guidance, these variables were excluded from the model, consistent with the intention-to-treat principle. All other variables with a univariate P0.10 (diabetes, statin use, IVUS guidance, initial reference diameter, initial MLD, and sex) were included in the multivariate analysis. Independent predictors of 6-month MLD were initial reference diameter (P<0.001), IVUS guidance (P=0.03), and statin use (P=0.045).yx;, 百拇医药

    Clinical Outcomeyx;, 百拇医药

    Table 3 summarizes the clinical events. Side-branch occlusion resulted in 1 Q-wave and 1 non–Q-wave MI in the angiography group and 1 non–Q-wave MI in the IVUS group. Procedural success was similar (96%) in both groups (P=NS). The in-hospital combined event rate was 3% for both groups (P=NS). At 1 month, 1 patient in each group had an episode of chest pain that could not be attributed to the treated vessel after repeated angiography.

    fig.ommittedj!s9|:, http://www.100md.com

    Clinical Eventsj!s9|:, http://www.100md.com

    Within 6 months, 1 patient with in-stent restenosis in the angiography group died of complications after bypass surgery. The ischemia-driven TLR rate was 4% (n=3) in the IVUS group and 14% (n=10) in the angiography group (P=0.037). In each group, 8 patients (11%) had a non–target-lesion intervention. At 6 months, the combined event rate (death plus MI plus TLR) was 6% in the IVUS group (n=4) and 20% in the angiography group (n=14; P=0.01).j!s9|:, http://www.100md.com

    From 6 to 12 months, 2 patients in the IVUS group died within 4 weeks after a non–target-lesion intervention: 1 due to heart failure, another of vascular complications (a Jehovah’s Witness who refused transfusions). The combined event rate (death plus MI plus TLR) at 12 months was 12% (n=9) in the IVUS group versus 27% (n=19) in the angiography group (P=0.026). The cumulative TLR rate at 12 months was 10% (n=7) in the IVUS-guided group versus 23% (n=17) in the angiography group (P=0.018). Cox regression analysis of the clinical events was done with a model that included all variables with P0.10 in univariate comparison (diabetes, statin use, IVUS guidance, and initial reference diameter). Guidance by IVUS was independently associated with a lower frequency of the combined end point of cardiac death, MI, and TLR at 6 months (P=0.025) and 12 months (P=0.016). Nonuse of a statin before the intervention was also an independent risk factor for occurrence of the combined clinical end point at 6 months (P=0.027) but not at 12 months.

    fig.ommitted8l)0-u1, 百拇医药

     Kaplan-Meier survival curves. A, Cumulative combined event-free survival. B, Cumulative freedom from TLR. ANGIO indicates angiographic guidance.8l)0-u1, 百拇医药

    Discussion8l)0-u1, 百拇医药

    The improved angiographic and clinical outcome of stenting long coronary stenoses with IVUS guidance is the principal finding of this study. This occurred despite the fact that patients randomized to IVUS guidance received more and/or longer stents, 2 characteristics notorious for their association with restenosis.4–68l)0-u1, 百拇医药

    Long lesions are a challenging subset because they are traditionally associated with poor outcome after balloon angioplasty or stenting.1–6 The only randomized study to investigate the use of stents in this subset showed less 6-month angiographic restenosis in the stent group (27%) than in the balloon group (42%; P<0.05) but no clinical benefit at 9 months.20 In a nonrandomized comparison, balloon angioplasty with IVUS-guided provisional spot stenting had a better long-term outcome than stenting with full lesion coverage.21 IVUS-guided patients in the present study had better angiographic and clinical outcomes than patients in either of these previous studies. In the present study, information obtained with IVUS apparently motivated the operators to stent atherosclerotic segments more extensively, despite similar lesion lengths in the angiography group. The extent of atherosclerotic disease is not accurately identified by angiography, and consequently, automated quantitative techniques may define stenosis borders as the place where compensatory vessel enlargement fails to preserve luminal dimensions, not where significant disease begins or ends.22 The present results indicate that complete coverage of the target lesion plus IVUS-guided optimal stent expansion offsets the unfavorable influence of more metal on late outcome. One explanation could be that stent dimension rather than length is the primary determinant of long-term outcome. Alternatively, the favorable flow characteristics associated with smooth transitions of slightly or nondiseased vessel to stented parts, as opposed to the disturbed flow that occurs with an abrupt transition of a significantly diseased vessel segment to a relatively smoother stented part, could positively influence the local reaction and late outcome.

    Generally, greater acute gain produces more injury and more late loss. However, similar to other reports,14 it did not result in increased late loss in the IVUS-guided group in the present study. Analogous to our findings regarding stent length and restenosis, we tend to ascribe this effect to optimization of the luminal geometry.@}^)g-[, 百拇医药

    The angiographic criteria for optimal stent placement (<30% residual stenosis) in the present protocol could be considered conservative, but because QCA data of the final result were similar in both groups, a bias of the interventionists in favor of the IVUS approach is unlikely. Because of a perceived difference in initial MLD in the cumulative frequency distribution curves, multivariate analyses were repeated to force baseline MLD into the model. This analysis confirmed that initial MLD was not an independent predictor of angiographic or clinical outcome at 6 or 12 months.23@}^)g-[, 百拇医药

    We also found that statin use was independently associated with better angiographic and clinical outcome. Although several researchers have found that smooth muscle cell proliferation is inhibited by statin use,24,25 only a few studies directly investigated the possible effects of this therapy on restenosis after stenting. The present data corroborate the reduction of in-stent restenosis and improved clinical outcome reported by Walter et al26 in a nonrandomized study of the effects of statins after stenting.

    Study Limitations!0, 百拇医药

    This was a single-center study with a relatively small sample size, but it was adequately powered to demonstrate the assumed difference between the strategies. Because we used 2 end points, an angiographic and a clinical parameter, to evaluate the difference between the 2 treatment strategies, it could be argued that correction for multiple testing (Bonferroni) should be used. This type of correction, however, would imply independence of angiographic and clinical outcome, but in our experience, these are highly correlated, which forms the basis for the use of angiographic outcome parameters as surrogate markers for event rate.27–29 The exclusive use of 1 stent type prohibits extension of these findings to the liberal use of other stents, because stent design may influence late outcome.30,31 Because only lesions >20 mm were included, these results may not be applicable to shorter lesions in which "baseline" restenosis rates are lower. Finally, there was a difference in abciximab use due to more difficulties in the IVUS group that resulted in flow impairment, but without an increase in clinical events.

    Conclusionst|, http://www.100md.com

    This study demonstrates an improved angiographic and clinical outcome after stent placement for long coronary stenoses guided by IVUS compared with angiographic guidance only. The initial results of drug-eluting stents for shorter lesions are promising, and in view of this report, the use of these new devices should be compared with the strategy of IVUS guidance when investigated in a lesion set comparable to that in the present study.t|, http://www.100md.com

    Acknowledgmentst|, http://www.100md.com

    This study was supported by an unrestricted research grant from Medtronic/AVE.t|, http://www.100md.com

    Referencest|, http://www.100md.com

    Bourassa MG, Lesperance J, Eastwood C, et al. Clinical, physiologic, anatomic and procedural factors predictive of restenosis after percutaneous transluminal coronary angioplasty. J Am Coll Cardiol. 1991; 18: 368–376.t|, http://www.100md.com

    Hirshfeld JW Jr, Schwartz JS, Jugo R, et al. Restenosis after coronary angioplasty: a multivariate statistical model to relate lesion and procedure variables to restenosis: the M-HEART Investigators. J Am Coll Cardiol. 1991; 18: 647–656.

    Pepine CJ, Allen HD, Bashore TM, et al. ACC/AHA guidelines for cardiac catheterization and cardiac catheterization laboratories: American College of Cardiology/American Heart Association Ad Hoc Task Force on Cardiac Catheterization. Circulation. 1991; 84: 2213–2247.r., 百拇医药

    Goldberg SL, Loussararian A, De Gregorio J, et al. Predictors of diffuse and aggressive intra-stent restenosis. J Am Coll Cardiol. 2001; 37: 1019–1025.r., 百拇医药

    Kastrati A, Elezi S, Dirschinger J, et al. Influence of lesion length on restenosis after coronary stent placement. Am J Cardiol. 1999; 83: 1617–1622.r., 百拇医药

    Kobayashi Y, De Gregorio J, Kobayashi N, et al. Stented segment length as an independent predictor of restenosis. J Am Coll Cardiol. 1999; 34: 651–659.r., 百拇医药

    Hoffmann R, Mintz GS, Mehran R, et al. Intravascular ultrasound predictors of angiographic restenosis in lesions treated with Palmaz-Schatz stents. J Am Coll Cardiol. 1998; 31: 43–49.r., 百拇医药

    Nakamura S, Colombo A, Gaglione A, et al. Intracoronary ultrasound observations during stent implantation. Circulation. 1994; 89: 2026–2034.

    de Feyter PJ, Kay P, Disco C, et al. Reference chart derived from post-stent-implantation intravascular ultrasound predictors of 6-month expected restenosis on quantitative coronary angiography. Circulation. 1999; 100: 1777–1783.2qw, 百拇医药

    Hong MK, Park SW, Mintz GS, et al. Intravascular ultrasonic predictors of angiographic restenosis after long coronary stenting. Am J Cardiol. 2000; 85: 441–445.2qw, 百拇医药

    de Jaegere P, Mudra H, Figulla H, et al. Intravascular ultrasound-guided optimized stent deployment: immediate and 6 months clinical and angiographic results from the Multicenter Ultrasound Stenting in Coronaries Study (MUSIC Study). Eur Heart J. 1998; 19: 1214–1223.2qw, 百拇医药

    Berry E, Kelly S, Hutton J, et al. Intravascular ultrasound-guided interventions in coronary artery disease: a systematic literature review, with decision-analytic modelling, of outcomes and cost-effectiveness. Health Technol Assess. 2000; 4: 1–117.2qw, 百拇医药

    Fitzgerald PJ, Oshima A, Hayase M, et al. Final results of the Can Routine Ultrasound Influence Stent Expansion (CRUISE) study. Circulation. 2000; 102: 523–530.

    Mudra H, Di Mario C, de Jaegere P, et al. Randomized comparison of coronary stent implantation under ultrasound or angiographic guidance to reduce stent restenosis (OPTICUS Study). Circulation. 2001; 104: 1343–1349.g, http://www.100md.com

    Schiele F, Meneveau N, Vuillemenot A, et al. Impact of intravascular ultrasound guidance in stent deployment on 6-month restenosis rate: a multicenter, randomized study comparing two strategies—with and without intravascular ultrasound guidance: RESIST Study Group: REStenosis after IVUS guided STenting. J Am Coll Cardiol. 1998; 32: 320–328.g, http://www.100md.com

    Nissen SE, Yock P. Intravascular ultrasound: novel pathophysiological insights and current clinical applications. Circulation. 2001; 103: 604–616.g, http://www.100md.com

    Reiber JH, van der Zwet PM, Koning G, et al. Accuracy and precision of quantitative digital coronary arteriography: observer-, short-, and medium-term variabilities. Cathet Cardiovasc Diagn. 1993; 28: 187–198.g, http://www.100md.com

    Blackburn H. Classification of the electrocardiogram for population studies: Minnesota Code. J Electrocardiol. 1969; 2: 305–310.

    Ryan TJ, Faxon DP, Gunnar RM, et al. Guidelines for percutaneous transluminal coronary angioplasty: a report of the American College of Cardiology/American Heart Association Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (Subcommittee on Percutaneous Transluminal Coronary Angioplasty). Circulation. 1988; 78: 486–502.+'3, 百拇医药

    Serruys P, Foley D, Suttorp MJ, et al. A randomized comparison of the value of additional stenting after optimal balloon angioplasty for long coronary lesions: final results of the Additional Value of NIR Stents for Treatment of Long Coronary Lesions (ADVANCE) study. J Am Coll Cardiol. 2002; 39: 393–399.+'3, 百拇医药

    Colombo A, De Gregorio J, Moussa I, et al. Intravascular ultrasound-guided percutaneous transluminal coronary angioplasty with provisional spot stenting for treatment of long coronary lesions. J Am Coll Cardiol. 2001; 38: 1427–1433.+'3, 百拇医药

    Escaned J, Baptista J, Di Mario C, et al. Significance of automated stenosis detection during quantitative angiography: insights gained from intracoronary ultrasound imaging. Circulation. 1996; 94: 966–972.

    Frey AW, Hodgson JM, Muller C, et al. Ultrasound-guided strategy for provisional stenting with focal balloon combination catheter: results from the randomized Strategy for Intracoronary Ultrasound-guided PTCA and Stenting (SIPS) trial. Circulation. 2000; 102: 2497–2502.afj8#'-, 百拇医药

    Gellman J, Ezekowitz MD, Sarembock IJ, et al. Effect of lovastatin on intimal hyperplasia after balloon angioplasty: a study in an atherosclerotic hypercholesterolemic rabbit. J Am Coll Cardiol. 1991; 17: 251–259.afj8#'-, 百拇医药

    Soma MR, Donetti E, Parolini C, et al. HMG-CoA reductase inhibitors: in vivo effects on carotid intimal thickening in normocholesterolemic rabbits. Arterioscler Thromb. 1993; 13: 571–578.afj8#'-, 百拇医药

    Walter DH, Schachinger V, Elsner M, et al. Effect of statin therapy on restenosis after coronary stent implantation. Am J Cardiol. 2000; 85: 962–968.afj8#'-, 百拇医药

    Azen SP, Mack WJ, Cashin-Hemphill L, et al. Progression of coronary artery disease predicts clinical coronary events: long-term follow-up from the Cholesterol Lowering Atherosclerosis Study. Circulation. 1996; 93: 34–41.

    Buchwald H, Matts JP, Fitch LL, et al. Changes in sequential coronary arteriograms and subsequent coronary events: Surgical Control of the Hyperlipidemias (POSCH) Group. JAMA. 1992; 268: 1429–1433.y6, http://www.100md.com

    Waters D, Lesperance J, Craven TE, et al. Advantages and limitations of serial coronary arteriography for the assessment of progression and regression of coronary atherosclerosis: implications for clinical trials. Circulation. 1993; 87 (suppl II): II-38–II-47.y6, http://www.100md.com

    Almagor Y, Feld S, Kiemeneij F, et al. First International New Intravascular Rigid-Flex Endovascular Stent Study (FINESS): clinical and angiographic results after elective and urgent stent implantation: the FINESS Trial Investigators. J Am Coll Cardiol. 1997; 30: 847–854.y6, http://www.100md.com

    Nageh T, de Belder AJ, Thomas MR, et al. A randomised trial of endoluminal reconstruction comparing the NIR stent and the Wallstent in angioplasty of long segment coronary disease: results of the RENEWAL Study. Am Heart J. 2001; 141: 971–976.(Pranobe V. Oemrawsingh MD Gary S. Mintz MD Martin J. Schalij MD PhD Aeilko H. Zwinderman PhD J. Wout)