The variable number of tandem repeat polymorphism of platelet glycoprotein Ib and risk of coronary heart disease
From the Department of Medicine, Thrombosis Research Section, Baylor College of Medicine, Houston, TX; and University of Texas at Houston Health Science Center, Houston.7vk, http://www.100md.com
Glycoprotein (GP) Ib-IX-V complex plays an important role in formation of platelet-fibrin clot at the area of damaged vessel wall. One polymorphism of GP Ib{alpha} , the main component of GP Ib-IX-V complex, is due to variable numbers of tandem repeats (VNTRs) in the macroglycopeptide region of this molecule. We studied the association between the presence of different VNTR alleles of GP Ib{alpha} and the frequency of coronary heart disease (CHD) among individuals recruited to a large community-based case-cohort study (Atherosclerosis Risk in Communities [ARIC] study). We found that the distribution of VNTR alleles of GP Ib{alpha} is different among whites and African Americans. The B allele (with 3 repeats) of GP Ib{alpha} is relatively more common among African Americans compared with whites. In African Americans, the CC genotype (homozygous with 2 repeats) is associated with a lower risk of CHD events than all other genotypes. (Blood. 2004;103:963-965)(Vahid Afshar-Kharghan Nevenka Matijevic-Aleksic Chul Ahn Eric Boerwinkle Kenneth K. Wu and José A. )
Glycoprotein (GP) Ib-IX-V complex plays an important role in formation of platelet-fibrin clot at the area of damaged vessel wall. One polymorphism of GP Ib{alpha} , the main component of GP Ib-IX-V complex, is due to variable numbers of tandem repeats (VNTRs) in the macroglycopeptide region of this molecule. We studied the association between the presence of different VNTR alleles of GP Ib{alpha} and the frequency of coronary heart disease (CHD) among individuals recruited to a large community-based case-cohort study (Atherosclerosis Risk in Communities [ARIC] study). We found that the distribution of VNTR alleles of GP Ib{alpha} is different among whites and African Americans. The B allele (with 3 repeats) of GP Ib{alpha} is relatively more common among African Americans compared with whites. In African Americans, the CC genotype (homozygous with 2 repeats) is associated with a lower risk of CHD events than all other genotypes. (Blood. 2004;103:963-965)(Vahid Afshar-Kharghan Nevenka Matijevic-Aleksic Chul Ahn Eric Boerwinkle Kenneth K. Wu and José A. )