【摘要】 目的 探讨应用骨髓腔内直接低压直流电刺激治疗兔桡骨节段性骨缺损中的作用。方法 将大耳白兔桡骨节段性骨/骨膜缺损模型中随机分为3组，A组(实验组):给予骨缺损区植入DBX，应用低压直流电刺激;B组(对照组):单纯DBX与BMP复合物植入;C组(空白组):不作任何处理。分别于2、5、9周取材，检测血清钙离子浓度，碱性磷酸酶(Alkaline Phosphatase，ALP)含量，并进行组织形态学及电镜疗效观察。结果 较对照组与空白组，实验组:①血清钙离子浓度，ALP含量在术后2周明显升高，统计学处理差异有显著性。②组织形态学及X线片观察A组成骨细胞增生、血管生成活跃，9周时骨缺损有新生骨桥接、骨改建进行，明显强于对照组。③超微结构正常。结论 应用髓腔内直接直流电刺激修复骨缺损作用明显，有良好的临床应用前景。

    关键词 直流电刺激 骨形态发生蛋白 髓腔 骨缺损 修复

    【文献标识码】 A 【文章编号】 1681-102X(2004)03-0218-04

    An experimental study on repairing of the rabbit radial defect with

    direct galvanic stimulation in medullary cavity

    Mei Qiang，Li Yongge，Zhu Yangjun，et al.

    Department of Orthopedics，China XD Group’s Hospital，Xi’an710077.

    【Abstract】 Objective To explore the influence of low constant direct current(LCDC)in the medullary cavity on repairing of rabbit radial defect so as to evaluate the value of its clinical application.Methods The rabbits whose biˉlateral radius were the models of the segmental osteoperiosteum defect were divided into3groups.Group A(Subject group):the defects with DBX were stimulated by LCDC;Group B(Control group):the defects were only filled with DBX+BMP;Group C:the defects were left untreated.Zn the2nd ......