【摘要】 目的 观察国内合成的抗肿瘤化合物二氯钛烯对荷瘤动物的抗肿瘤作用，为抗癌新药的研究和开发提供实验依据。方法 按Bliss法测定二氯钛烯对小鼠的半数致死剂量(LD 50 )，在小鼠体内观察二氯钛烯对四株移植性实体瘤的抑瘤率，以评价二氯钛烯的抗

    肿瘤疗效。结果 二氯钛烯静脉注射时对小鼠的LD 50 为56.23mg/kg。对荷瘤小鼠肝癌(H-22)、肉瘤(S-180)和肺癌(LLC)的抑瘤率分别为77.4%、73.4%和76.4%，对荷人胃癌(BGC-823)裸鼠的抑瘤率为61.6%。结论 二氯钛烯具有较强的抗肿瘤活性，有较好的开发应用潜力。

    关键词 二氯钛烯 抗肿瘤作用

    Studies on the anticancer effects of titanocene dichloride in vivo experiment

    Liu Tong，Su Hong，Wang Naiqin，et al.

    Department of Clinical Pharmacology，The School of Oncology，Peking University，Beijing100034.

    【Abstract】 Objective To investigate the acute toxicity and anticancer action of titanocene dichloride in vivo.Methods The LD 50 of titanocene dichloride was determined in normal mice.In the anticancer test on transplantable solid tumor in mice seek to obtain inhibitory tumor rate of titenocene dichloride.Results The LD 50 of titanocene dichloride was56.28mg/kg.The inhibitory tumor rate of titanocene dichloride(iv)for transplantable solid tumor in mice were77.4%(H-22)、73.4%(S-180)、76.4%(LLC)and61.6%(BGC-823)respectively.Conclusion The anticancer actions of titanocene dichloride in vivo were obviousness and have potential for development as a new drug in cancer therapy.Key words titanocene dichloride anticancer effects ......