【摘要】 目的 探讨热疗、羟基喜树碱(HCPT)及放疗联合应用对荷Lewis肺癌的C57BL小鼠的抗肿瘤作用。方法 采用肿瘤生长延迟(TGD)分析热、化、放联合应用对荷Lewis肺癌的C57BL小鼠的抗肿瘤作用。结果 (1)41℃、42℃、43℃热疗的TGD分别为1.07、1.40、2.52天。(2)41℃、42℃、43℃热化疗联合的TGD分别为4.86、5.57、7.14天，均明显优于对照组。(3)41℃、42℃、43℃热放疗联合的TGD分别为7.71、8.43、8.82天，均长于单纯放疗组的6.28天。(4)40℃、42℃、43℃热化放疗联合的TGD分别为11.01、13.07、15.195天，均明显优于各热放、热化及放化组。结论 (1)热疗对Lewis肺癌的抑制作用随温度的增高而增高。(2)热疗增加HCPT及放疗的抗肿瘤作用。(3)热化放三联治疗的疗效优于单一和任意二联组。

    radiotherapy trimodalities on C57BL mice with Lewis lung cancer

    Zhang Hongtao，You Qingshan，Wang Ruizhi

    Department of Radiotherapy，Affiliated Hospital of Oncology，Harbin Medical University，Harbin150040.

    【Abstract】 Objective To assess the antitumor value of hyperthermia，hydroxycamptothecine(HCPT)，and raˉdiotherapy on C57BL mice with Liwis lung cancer.Methods (1)Tumor Growth Delay(TGD)were analysised at difˉferent groups.Results (1)The TGD obtained at41℃，42℃，43℃hyperthermia were respectively1.07，1.40，2.52days.(2)The TGD acquired at41℃，42℃，43℃thermo-chemothrapy were respectively4.86，5.57，7.14days，and were all prolonged.(3)The TGD acquired at41，42，43℃thermo-radiothrapy were respectively7.71 ......