【摘要】 目的 观察P糖蛋白(Pgp)在骨肉瘤组织中的表达，探讨P糖蛋白对骨肉瘤预后的临床价值。方法 采用免疫组织化学方法检测21例骨肉瘤组织中P糖蛋白的表达。结果 14例预后不良骨肉瘤组织中的P糖蛋白表达阳性率为78.6%(11/14)，7例预后良好骨肉瘤组织中表达阳性率为14.3%(1/7)，两者相比差异有显著性(P<0.05)。结论 P糖蛋白表达与骨肉瘤预后密切相关，检测骨肉瘤组织中P糖蛋白的表达对判断骨肉瘤患者的预后具有重要的临床价值。

    关键词 骨肉瘤 P糖蛋白 免疫组化

    Expression and clinical significance of P-glycolprotein in patients with osteosarcoma

    Wang Xiaobo

    The Hospital of Ostedogy，Wendeng，Shandong264400.

    【Abstract】 Objective To study the expression of P-glycolprotein in patients with osteosarcoma and its clinˉical significance.Methods The expression of P-glycolprotein was measured by immunohistochemical technique in21patients with osteosarcoma individuals.Results In7samples from patients with osteosarcoma whose prognosis was good.P-glycolprotein positive rate was14.3%(1/7).In14samples from patients with osteosarcoma whose prognosis was not good ......