【摘要】 目的 分析肺癌患者血清血管内皮生长因子(VEGF)水平变化及其影响因素，以探讨其临床意义。方法 采用双抗夹心ELISA方法检测47例肺癌患者血清VEGF水平(157.97±135.62pg/ml)，并与40例健康体检者的血清VEGF水平作对比分析。用SPSS10.0统计软件包进行统计分析。结果 肺癌患者的血清VEGF水平(157.97±135.62pg/ml)显著高于正常对照组(51.23±22.66pg/ml)，两者相比差异具有非常显著性(P=0.000)。肺癌患者血清VEGF水平分别受临床分期、肿瘤淋巴转移和远处转移等因素的影响。结论 血清VEGF可能成为一个新的肿瘤标志物，用于肺癌的诊断和病情进展的动态监测指标。

    关键词 肿瘤 血清 血管内皮生长因子 临床意义

    Level of vascular endothelial growth factor in the sera of patients with lung cancer and its clinical significance

    Liu Weiping，Chen Yan，Wu Zhiping，et al.

    Department of Respiration，The Second Hospital Affiliated to Kunming Medical College，Kunming650101.

    【Abstract】 Objective To explore changes and influent factors of serum vascular endothelial growth factor(VEGF)level in patients with lung cancer and to evaluate its clinical significance.Methods Serum VEGF in the samples from47patients with lung cancer were detected by Sandwich enzyme-linked immunosorbent assay(ELISA).Forty normal healthy persons served as control.Statistical analysis was performed by using the SPSS10.0software package.Results Serum VEGF level of patients with lung cancer(157.97±135.62pg/ml)was significantly higher than that in control group(51.23±22.66pg/ml) ......