【摘要】 目的 探讨内皮素-1(endothelin-1，ET-1)与门静脉高压性胃病的关系。方法 采用门静脉部分结扎制备肝前性门静脉高压症模型，模型制备完毕，测定门静脉压力;放射免疫法测定胃粘膜组织ET-1含量;免疫组化染色观察ET-1在胃粘膜组织中的定位及表达。结果 模型组门静脉压力显著升高(17.38±2.19)vs(4.12±1.28mmHg，P<0.05);门静脉高压症大鼠胃粘膜组织中的ET-1含量(27.85±9.29)vs(6.32±1.13pg/g，P<0.05)以及免疫组化ET-1的表达水平较对照组均显著升高。结论 ET-1在门静脉高压性胃病的发病机制中起重要作用。

    关键词 内皮素-1 门静脉高压性胃病 大鼠

    Effect of endothelin-1in gastric mucosa of PPVL rats

    Zhang Xiefu，Xu Bing

    Department of Surgery，the First Affliated Hospital of Zhengzhou University，Zhengzhou450052

    【Abstract】 Objective To investigate the role of endothelin-1(ET-1)in thepathogenesis of portal hyperˉtensive gastropathy(PHG).Methods Portal hypertensive gastropathy model was induced by partial portal vein ligation(PPVL).After the model was established ......