【摘要】 目的 探讨烟台市原发性肝癌的危险因素。方法 按性别、年龄、职业、文化程度、居住地1:1配对原则，选择101例原发性肝癌病例和对照，采用单因素和多因素条件Logistic回归分析。结果 单因素分析发现，本人肝病史(急、慢性肝炎及肝硬化史)、家族肝病史(一系三代、本人及上下各一代，肝病史包括急慢性肝炎史、肝硬化史及肝癌史)、吃咸鱼史、饮酒史、HBsAg、HBsAb、HBcAb、HBcAbIgM、HBeAg、HBeAb、HBV总感染率与原发性肝癌有关。多因素分析发现本人肝病史(OR=25.9141)、家族肝病史(OR=16.2822)、HBsAg(OR=10.1362)、HBcAb(OR=14.2186)、HBeAg(OR=4.9308)、HBeAb(OR=9.0879)、HBV总感染率(OR=6.3566)是烟台市居民原发性肝癌的危险因素。而HBsAb(OR=0.2842)是原发性肝癌的保护因子。结论 原发性肝癌是多因素相互作用的结果，应采取干预措施，改变其影响因素。通过健康教育，乙型肝炎疫苗接种等策略来控制原发性肝癌的发生。

    关键词 原发性肝癌 危险因素 病例对照研究

     【文献标识码】 A 【文章编号】 1680-6115(2004)07-0586-04

    A case-control study on the risk factors of primary hepatocellular carcinoma in Yantai

    Jiang Gui′e，Wang Xinhua，Guo Yanmei，et al.

    Sanitation and Anti-epidemic Station of Zhifu District，Yantai264001.

    【Abstract】 Objective To investigate the risk factors of primary hepatocellular carcinomas(PHC)in Yantai city.Methods 1:1case-control study was conducted on101cases and101controls on the basis of sex，age，occuˉpation，educated level and location.The relationship between the risk factors and PHC were analyzed by conditional uˉnivariate and multivariate logistic regression.Results Seven risk factors which are responsible for the incidence of PHC were identified as follows:private hepatopathy history(OR=25.9141) ......