【摘要】 目的 测定单纯性肥胖患者血清生长激素释放肽(ghrelin)的水平，分析ghrelin与肥胖、血糖、胰岛素的相关性。方法 利用酶标法测定血清ghrelin;用放免法测定胰岛素。结果 与正常对照组相比，单纯性肥胖患者血清ghrelin水平是下降的;血清ghrelin与体重、体重指数呈负相关(P<0.05)，与身高、空腹血糖无关(P>0.05)，与空腹胰岛素(P<0.01)、胰岛素抵抗(HOMA-IR)(P<0.05)负相关，与胰岛素敏感性指数(ISI)呈正相关(P<0.01)。结论 单纯性肥胖患者血清ghrelin水平是下降的，其下降的机制可能是胰岛素抵抗所致。

    关键词 单纯性肥胖 生长激素释放肽

    The relationship between human serum ghrelin levels and serum glucose as well as insulin concentrations in human simple obesity

    You Li，Peng Yongde，Wang Yufei，et al.

    Department of Endocrinology，The First People’s Hospital of Shanghai，Shanghai200080.

    【Abstract】 Objective To investigate the relationship between human serum ghrelin and serum glucose levels as well as insulin levels in human simple obesity.Methods Serum ghrelin levels were measured by EIA，serum inˉsulin levels were measured by RIA.Results The serum ghrelin level of simple obesity group showed significantly lower than that of normal group ......