【摘要】 目的 分析血清脂蛋白(a)[lipoprotein(a)，Lp(a)]浓度在几种疾病中的变化来探讨其临床诊断价值。方法 应用免疫透射比浊法测定386例6组疾病患者和200例健康体检者的血Lp(a)含量，并进行比较。结果 除肝病组Lp(a)浓度明显下降(P<0.001)外，其余冠心病组、脑梗塞组、糖尿病肾病组、肿瘤组以及急性时相反应(APR)组患者Lp(a)浓度显著高于正常对照组(P<0.001)。结论 血清Lp(a)除可作为动脉硬化性心脑血管疾病的危险因素指标外，Lp(a)的增高还与糖尿病肾病、肿瘤以及急性时相反应性疾病相关联，而Lp(a)的降低提示肝病导致Lp(a)在肝脏中的合成减少。

    关键词 脂蛋白(a) 动脉硬化性心血管疾病 急性时相反应

    Application of serum Lp(a)measurement result in diagnosing relational diseases

    Lan Qingping，Xiong Daqian

    Department of Clinical Laboratory，Affiliated Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu610072.

    【Abstract】 Objective To analyze the changes of lipoprotein(a)[Lp(a)]level in patients with several kinds of diseases and investigate its diagnoses value.Methods 386patients with six kinds of diseases and200cases of norˉmal control were analyzed.Serum Lp(a)was determined by immune transmit turbid assay(ITA).Results Level of Lp(a)of patients with hepatic disease had signficantly decreased(P<0.001).Except that there were significant raise in other diseases such as CHD ......