【摘要】 目的 探讨显微外科手术后间质化疗联合增敏放疗治疗脑胶质瘤的临床疗效。方法 对45例恶性脑胶质瘤患者行开颅显微手术全切除，术中于瘤腔内安置化疗囊，并行化疗药物体外敏感性及放疗增敏作用检测，术后第2、4、8、12周和6个月分别行经皮穿刺注入敏感化疗药物联合增敏放疗。随访6～36个月，并与以前随访的40例接受肉眼下全切后常规放化疗的脑胶质瘤患者相比较。结果 45例患者均获随访，生存期明显延长，半年内复发4例(8.9%)，死亡3例(6.7%);1年内复发9例(20.0%)，死亡7例(15.6%);2年内复发19例(42.2%)，死亡15例(33.3%);3年内复发25例(55.6%)，死亡22例(48.9%)。未发现明显的毒副反应，生存质量得到明显改善。结论 显微外科手术力争全切除，术后敏感药物间质化疗联合增敏放疗，是一种可供选择的治疗人脑恶性胶质瘤的安全有效方法。

    【关键词】 胶质瘤 显微外科手术 间质化疗 增敏放疗

    Treatment of malignant brain gliomas using interstitial chemotherapy combined

    with sensitive radiotherapy after microsurgical excision

    Bu Xingyao，Zhao Hongwei，Luo Jianchao，et al.

    Department of Neurosurgery，Henan Provincial People’s Hospital，Zhengzhou450003

    【Abstract】 Objective To investigate the effect of interstitial chemotherapy combined with sensitive radiotherˉapy on malignant brain gliomas after microsurgical excision.Methods In45patients with malignant brain gliomas，the tumor was microsurgically removed and interstitial chemotherapy bursa were embeded in the tumor bed during operˉation.The drug of chemotherapy and sensitive radiotherapy was selected by drug sensitive test in vitro.The sensitive drug was injected into chemotherapy bursa in the2nd.4th.8th.12th week and6months after operation respectively.Concurrently ......