【摘要】 目的 探讨增溶瑞香素的稳定囊泡作为药物载体的优越性。 方法 选择生理上能接受的2种表面活性剂，即仿生磷酯阳离子表面活性剂PTA与阴离子表面活性剂SDS，按一定比例复配能自发形成稳定性囊泡，用负染色透射电镜和动态光散射对其进行表征，并以其作为药物瑞香素的载体开展其组成、温度对包封率的影响，以及在模拟胃液及模拟肠液中的释放情况的研究。 结果 在表面活性剂总浓度为5.0×10 -3 mol/L，PTA/SDS=3∶7时，囊泡粒径最大为151.1nm，包封率最高为28.2%。它们在模拟胃液和模拟肠液中释放75%的时间分别为240min和340min。 结论 本研究对于阴阳离子表面活性剂复配自发形成囊泡作为药物载体进行了探索性工作，并对实验现象和结果从理论上进行讨论，为今后的研究指出方向。

    关键词 囊泡 瑞香素 粒径 包封率 释放分数 药物载体

    Study on drug delivery of the stablized vesicles with daphnetin solubilization

    Hu Changgang，Wang Zhongni，Li Ganzuo，et al.

    Key Lab for Colloid and Interface Chemistry of State Education Ministry，Shandong University，Ji'nan250100.

    【Abstract】 Objective To study drug delivery of the stable vesicles with daphnetin solubilization.Methods Stable vesicles were formed from mixed solution of cation surfactant PTA and anion surfactant SDS at proper propor-tions.The formation and characters of the vesicles were demonstrated by negative-staining TEM and dynamic light scattering.Using the vesicles as the delivery of daphnetin，we carried out the research on the effect of formation and temperature upon entrapment efficiency.Research had also been carried out upon the release circumstance of daph-netin contained in the vesicles in simulated gastric and intestinal fluid.Results The results showed that entrapment efficiency of the vesicles reached a max of28.2% ......