【摘要】 目的 研究胂酸基乙酸(Arsenacetylic acid，ASAC)对H22肝癌荷瘤小鼠移植瘤的抑制作用。 方法 以尾静脉注射方式，观察ASAC对昆明小鼠的急性毒性作用并求出LD50。再以小鼠肝癌H22细胞株为研究对象，观察静脉注射ASAC的剂量分别为LD50的1/3、1/6、1/12时，ASAC对H22肝癌在小鼠体内生长的抑制作用及其毒副反应。 结果 ASAC静脉注射260mg/kg、130mg/kg、65mg/kg均能在小鼠体内诱导肝癌细胞凋亡。在260mg/kg剂量组，凋亡诱导最明显，并有显著的抑制肿瘤生长的作用，抑瘤率为46.6%。经病理组织学检查显示260mg/kg和130mg/kg剂量组对心脏和肝脏有轻度毒性，但260mg/kg出现了小鼠中毒死亡的现象。 结论 ASAC对荷H22小鼠肿瘤有一定的治疗作用，但存在最适剂量问题。其抑瘤机制还未探明，但诱导凋亡和分化可能是ASAC起到的主要作用。

    关键词 荷瘤小鼠 胂酸基乙酸 肝癌 病理学 药理学 凋亡

    Inhibition effect of arsenacetylic acid on experimental H22hepatoma bearing mice in vivo

    Guo Lixia，Wang Yuanliang，Xiao Xu，et al.

    Bioengineering College of Chongqing University，Key Laboratory of Biomechanics and Tissue Engineering under Ministry of Education，Chongqing400044.

    【Abstract】 Objective To investigate the antitumor effects of arsenacetylic acid(ASAC)on solid tumor in vi-vo，the transplanted H22hepatoma of mice were treated with various dosages of ASAC.Methods After ASAC were injected via tail vein，acute toxicity were observed and obtained LD50.Hepatic carcinoma cells were transplanted sub-cutaneously to Kunming mice to produce tumor.The tumor inhibition rate in vivo was observed after intraperitoneally administering of ASAC.The histopathologic change in the tumor tissue ......