【摘要】 目的 探讨中国人原发系统性间变性大细胞淋巴瘤(Anaplastic Large Cell Lymphoma，ALCL)的临床病理特点、免疫表型及其与西方人的差异。方法 光镜下观察18例ALCL的病理形态，并用免疫组化(SP法)研究其免疫表型。结果 瘤细胞形态多样，常可见肾形或马蹄形核。瘤细胞常沿副皮质区和窦内浸润。免疫组化标记6例为T细胞性，12例为裸细胞性，CD30阳性16/18例(88.89%)，EMA阳性11/15例(73.33%)，ALK阳性12/18例(66.67%)，Granzyme B阳性6/12例(50%)，TIA-1阳性3/9例(33.33%)。结论 ALCL形态学范围较宽，免疫组化检测CD30、EMA、ALK、Granzyme B、TIA-1等，对其诊断和鉴别诊断有重要意义。中国人ALCL的临床病理及免疫表型特点与西方人相近。

    关键词 间变性大细胞淋巴瘤免疫表型 CD30 ALK Granzym B

    Clinicopathological and immunohistochemical study of primary systemic

    anaplastic large cell lymphoma

    Kong Xiuzhen，Li Min，Li Jie，et al.

    Department of Pathology，Peking University，Beijing100083.

    【Abstract】 Objective To study the clinicopathological characteristics and immunophenotype of primary sysˉtemic anaplastic large cell lymphoma(ALCL)comparing with Western cases.Methods 18cases of ALCL were studˉied by the method of morphology observation and immunohistochemistry stain(SP).Results The tumor cells are pleoˉmorphic ......