【摘要】 目的 评价去甲万古霉素对老年危重病人肾功能的影响并与万古霉素相比较。方法 采用回顾性分析的方法，选择耐甲氧西林金黄色葡萄球菌感染的危重病人86例，去甲万古霉素治疗的患者50例，万古霉素对照组36例。根据每例病人血清肌酐清除率计算去甲万古霉素或万古霉素每天使用剂量，连续静点至少大于5天，观察用药前后肾功能的改变。结果两组治疗前后BUN，Scr，尿蛋白的变化经统计学处理差异无显著性(P>0.05)。结论 去甲万古霉素对老年危重病人肾功能的影响是安全的。

    关键词 去甲万古霉素 万古霉素 耐甲氧西林金黄色葡萄球菌

    The effect of kidney function of older serious pations on norvancomycin

    Zhao Wenxian，Zhang Xiaguang，Chen Xiukai，et al.

    Beijing Puren Hospital，Beijing100062

    【Abstract】 Objective To evaluate the effect of kidney function of older serious patients using norvancomycin as compare with vancomycin.Methods A review analysis was conducted，we chose eighty-six older serious patients in methicillin-resistant staphylococcus aureus(MRSA)as our object，fifty patients for norvancomycin and thirty-six for vancomycin.Patients had been injected the corresponding dosage calculated from their GFR for over5days ......