【摘要】 目的 观察短期胰岛素泵强化治疗对初诊2型糖尿病患者的胰岛β细胞功能的影响。方法 收集16例初诊2型糖尿病患者进行为期2周的胰岛素泵强化治疗，比较治疗前后空腹血糖(FPG)及餐后2h血糖(2hPG)、口服葡萄糖耐量(OGTT)试验、胰岛素分泌指数(I30/G30)和胰岛素曲线下面积(AUC)、由Homa模型计算的HomaA胰岛素抵抗指数及Homa B胰岛素分泌指数的变化。结果 经2周胰岛素泵强化治疗，空腹血糖及餐后2h血糖明显降低，I 30 /G 30 、胰岛素曲线下面积及Homa B指数明显升高，而HomaA指数明显降低。结论 初诊2型糖尿病应用胰岛素泵治疗可快速控制血糖及显著改善胰岛β细胞功能。

    关键词 2型糖尿病 胰岛素 胰腺β细胞 葡萄糖耐量

    Clinical Observation of the effect of insulin pump treatment in newly diagnosed type 2 diabetic patients

    Zhu Yamei，Qu Gengru，Dong Yanhu

    Qingdao Endocrine and Diabetic Hospital，Qingdao266071.

    【Abstract】 Objective To study the impact of short-term intensive insulin pump treatment on β-cell function in newly diagnosed type 2 diabetic patients. Methods 16 newly diagnosed type 3 diabetic patients were treated with continuous insulin pump treatment for two weeks and their β-cell function was assessed before and after the insulin pump treatment by oral glucose tolerance test. Results Two weeks after the treatment ......