【摘要】 目的 探讨胎盘中滋养细胞凋亡和内源性一氧化氮(NO)与分娩发动的关系。 方法 对未临产和临产的两组足月孕妇胎盘组织，应用TUNEL法检测凋亡细胞，并计算出凋亡指数(AI)，同时应用免疫组化法分析诱导型一氧化氮合酶(iNOS)的表达。 结果 临产组胎盘绒毛滋养细胞AI和iNOS表达均较未临产组有明显升高，差异有显著性(P<0.05)。 结论 胎盘中细胞凋亡指数增加和iNOS活性上升均可能与分娩发动有关。

    关键词 胎盘 细胞凋亡 一氧化氮合酶 分娩发动

    Relationship between cellular apoptosis together with activity of inducible nitric oxide synthase in placenta at term pregnancy and labor onset

    Hu Shuangjiu，Zhao Yue

    Department of Obstetrics and Gynecology，The Second Affiliated Hospital，Harbin Medical University，Harbin150080.

    【Abstract】 Objective To study the relationship between the initiation of labor and the trophoblast apoptosis together with the endogenous nitric oxide(NO)in the placenta.Methods Placental samples were collected from pa-tients of both the non-labor group and the vaginal delivery group at term.The TUNEL method was used to detect apoptosis in each of these tissues，and then the apoptotic index(AI)was calculated.At the same time immunohistoche-mistry was used to assess iNOS.Results The AI of placental trophoblast and the activity of iNOS in labor group were both higher than those before labor ......