韩德五 赵龙凤 山西医科大学肝病研究所，太原030001 基础医学与临床 1999 0 19 6


    关键词：Endotoxemia/Intestinal Hepatitis Fibrosis Cirrhosis Hepatocarcinoma 期刊 jcyxylc 0 肝炎慢化与重型化机理 fur -->


    

ABSTRACT ：It thas been reported that the various experimental liver injuries and patients with liver diseases are accompanied by intestinal endotoxemia (IETM).Up to now ，the effect of IETM on the chronicity of hepatitis，its pervention and treatment have received little attention.

    According to the study of a large number of animal experiments and clinics，we raise a new conception of the pathogenesis of hepatic injury in hepatitis:The various factors induce liver injury(for example，hepatic virus，alcohol，medicines and hepatotoxic agents and so on )by various specific mechanisms，which is called “The primary liver injury”.IETM is occurred in the deveopment of hepatitis.Endotoxin activated kupffer cells and produced a number of chemical mediators.The liver injury caused by mediators is called”The secondary liver injury”.This “The secondary liver injury”depends on serious degree of IETM.The repeated and persistent hepatocellular necrosis in light IETM condition accompanying hepatocellular regeneration and inflammatory cells infiltration develop the chronic hepatitis and/or liver fibrosis ......