周建中 雷寒 陈运贞 李法琦 重庆医科大学附属第一院内科 重庆 400016 高血压杂志 2000 0 8 1


    关键词：自发性高血压大鼠；心室重构；福辛普利；依那普利；超微结构 期刊 gxyzz 0 61-63 基础医学研究 fur -->


    

摘 要：目的: 观察血管紧张素转换酶抑制剂enalapril和fosinopril对SHR心肌超微结构的逆转作用。方法： 将10月龄18只SHR随机分为Enalapril(SHR_E )、Fosinopril(SHR_F ) 和生理盐水(SHRc) 三组，给药剂量为10 mg/kg/d腹腔内注射8周。测定血压、心室重量指数，电镜观察心肌超微结构改变。结果: 两药物组心室肥厚均不同程度消退，部分逆转心肌超微结构改变，而且Fosinopril降低LVW/BW比Enalapril更好(P<0.05)。结论: 福辛普利和依那普利不同程度改善心肌细胞超微结构损害。

    分类号： R972;R541.3;N33 文献标识码： A

    文章编号： 1006-2866(2000)01-0061-02

Reversal of Cardiomuscular Ultrastructural Lesions by Enalapril or F osinopril in Spontaneous Hypertensive Rats

ZHOU Jianzhong LEI Han CHEN Yunzhen LI Faqi

    (Department of Internal Medicine,The firstAffiliated Hospital,Chongqin g University of Medical Sciences )

ABSTRACT ： Aim : Thestudy was to observe the effects of angiotensin con verting enzyme inhibitor enalapril and fosinopril on reversal ofcardiomuscular ultrastructure in spontaneous hypertensive rats.Methods: 18SHRs were divided into three groups at random. Enalapril or Fosinopril or saline (10mg/kg/d) was injected intraperitoneally into each group rat. Systolic blood pressure andventricular weight index (LVW/BW,RVW/BW) were measured. cardiomuscular ultrastru cturalwas observed with electron-microscope.Results: The effects of enalapriland fosinopril were similar in decreasing SBP,RVW/BW. Decreased LVW/BW in fosinopril wasmore significantly than that by enalapril. Both drugs can par tly reverse thecardiomuscular ultrastructure lesions.Conclusion: Enalapril and fosinoprillead to reverse the cardiomuscular ultrastructure at varying degrees.

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