关键词：肺纤维化；呼吸功能不全；氧吸入疗法
摘要 目的： 评价一种氧疗环境控制单位——氧帐改善肺间质纤维化所致重症呼吸衰竭患者的氧疗效果。方法： 对12例终末期肺间质纤维化所致重症呼吸衰竭患者采用Origin D型氧帐吸氧，氧流量为12 L/min～15 L/min，维持帐内吸入氧气，浓度为45%～50%,CO2 浓度<1%。结果： 结果显示，采用氧帐吸氧后0.5 h，较氧帐治疗前采用普通鼻导管吸氧的动脉血氧分压(PaO2 )与动脉血氧饱和度(SaO2 )明显提高(氧帐治疗前后PaO2 分别为5.5±0.7 kPa和8.6±1.0 kPa；SaO2 分别为79.9±3.1%和88.4±4.7%)。9例病情稳定并撤离氧帐，平均氧帐使用时间为67.8±18.9 h；2例死于多脏器功能衰竭，1例死于消化道出血。结论： 氧帐可作为抢救终末期肺间质纤维化所致重症呼吸衰竭患者的有用手段，可改善缺氧状态，赢得临床控制感染时间，改善预后。
ROLE OF OXYGEN TENT IN TREATMENT OF SEVERE RESPIRATORY FAILURE INDUCED BY LATE PULMONARY FIBROSIS
Lin Jiangtao,Cheng Lizhu,Zhang Xiulan,et al
(Department of Respiratory Diseases)
Abstract Objective: To evaluate the efficiency of oxygen therapy with an environmental control unit-oxygen tent in management of severe respiratory failure induced by pulmonary fibrosis.Methods: Twelve pulmonary fibrosis patients complicated with severe respiratory failure inhalated oxygen from Origin D type oxygen tent.Oxygen flow were designed as 12-15 L/min to maintain the oxygen concentrations between 45% and 50%,and carbon dioxide below 1%. Results: PaO2 and SaO2 were increased significantly after half an hour of oxygen tent therapy compared with that of common nasal canula.PaO2 were 5.5±0.7 kPa and 8.6±1.0 kPa,SaO2 were 79.9±3.1% and 88.4±4.7% respectively before and after oxygen tent therapy.Nine patients got stable and withdrawn from oxygen tent.The mean time of using oxygen tent was 67.8±18.9 hours.Two patients died from multiple organ failure and one from gastrointestinal hemorrhage.Conclusion: Oxygen tent is a useful tool in management of severe respiratory failure induced by late pulmonary fibrosis.It can improve the efficiency of gas exchange and prognosis.
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