关键词:充血性心力衰竭;心钠素;鹿角方
摘要 目的 :为了观察鹿角方对充血性心力衰竭(CHF)大鼠血浆心钠素(ANF)的影响。方法 :采用实验性腹主动脉银夹狭窄大鼠模型,观察左室重量指数(LVMI),放免测定血浆ANF。结果 :模型组血浆ANF水平较假手术组明显升高(P<0.01),鹿角方大剂量组和鹿角方小剂量组血浆ANF水平较模型组显著下降(P<0.01,P<0.05);模型组LVMI较假手术组显著升高(P<0.01),鹿角方大剂量组和鹿角方小剂量组LVMI较模型组明显下降(P<0.01,P<0.05)。结论 :鹿角方具有逆转CHF大鼠左室肥厚及降低血浆ANF水平的作用。
中图法分类号 R541.61
EFFECT OF LUJIAOFANG ON PLASMA ATRIAL NATRIURETIC FACTOR IN THE RAT WITH CONGESTIVE HEART FAILURE
Cai Hui,Hu Wanying
(Nanjing general hospital of PLA, Nanjing 210002 )
ABSTRACT Objective :Toconfirm the change of plasma atrial natriuretic factor(ANF) in the rat with congestiveheart failure(CHF) and effect of Lujiaofang.Methods :Left ventricular massindex(LVMI),plasma ANF was measured in the rat model by abdominal aorticconstriction.Plasma ANF was measured by radioimmunoassay.Results :It wasshowed that plasma ANF of model group was increased(P<0.01,vs control group),whileplasma ANF of high dose and low dose of Lujiaofang groups weredecreased(P<0.01,P<0.05,vs model group respectively);and LVMI of model group wasincreased(P<0.01,vs control group),while LVMI of high dose and low dose of Lujiaofanggroups were decreased(P<0.01,P<0.05,vs model group respectively).Conclusion :Leftventricular hypertrophy in the rat with CHF is regressed by Lujiaofang and plasma ANFlevel is decreased by it.
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