金沈锐 郑军 刘绍唐 金沈锐 郑军 刘绍唐(成都中医药大学 基础医学院，四川 成都 610075) 成都中医药大学学报 1999 0 22 1


    关键词：痛风；高尿酸血症；小鼠；动物模型 期刊 cdzyydxxb 0 实验动物模型研究 fur -->


    

摘 要 ：目的：探索建立小鼠高尿酸血症模型的方法。方法：使用黄嘌呤600mg/kg和乙胺丁醇250mg/kg，次黄嘌呤600mg/kg和烟酸100mg/kg， ig给药连续5天。结果：给药两组与正常对照组之间，小鼠血尿酸有显著性差异(P<0.05)。以黄嘌呤和乙胺丁醇组更为明显。结论：提示该两种方法可作为小鼠高尿酸血症动物模型。

    中图分类号：R589 文献标识码:B 文章编号 :1004-0668(1999)01-0049-02

Preliminary Studies on Animal Models of Hyperuricemic Mice

JIN Shenri, ZHENG Jun, LIU Shaotang (金沈锐，等)

    Basic Medicine College, Chengdu University of TCM (Chengdu, 610075,China)

SUMMARY ：Purpose: In search of procedures to establish hyperuricemic mice animal models. Way: Using xanthine (600mg/kg) and ethambutol (250mg/kg), hypoxanthine (600mg/kg) to i.g. mice for 5 ays. Result: The animal models of hyperuricemic mice were gotten. Conclusions: These hyperuricemic mice may be serve as animal models for hyperuricemia.

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