周 湘 蓬 蕊 庞 宁 赵庆丽 周 湘 副主任医师；蓬 蕊 庞 宁 赵庆丽 (儿 科 内分泌科) 中日友好医院学报 1999 0 13 1


    关键词：肾变病综合征；肾功能衰竭；三碘甲状腺原氨酸；甲状腺素；促甲状腺素 期刊 zryhyyxb 0 临床研究 fur -->


    

摘要 目的： 探讨儿童肾病综合征(NS)和慢性肾衰竭(CRF)导致甲状腺功能异常改变的机理，及在血浆蛋白异常改变时采用游离三碘甲状腺原氨酸(FT₃ )、游离甲状腺素(FT₄ )和促甲状腺素(TSH)测定法评价甲状腺功能。方法： 采用酶学免疫测定法检测了15例肾脏疾病患儿的血清FT₃ 、FT₄ 和TSH。其中8例为NS,7例为CRF。并与7例NS恢复期(RENS)患儿及9例正常儿童(NC)为对照。结果： 与RENS和NC对照组相比，NS组的FT₄ 降低、TSH升高(均P<0.05)。CRF组FT₄ 和FT₃ 均明显降低(P<0.05)，而TSH无明显改变(P>0.05)。RENS的各项指标与NC无差异(P>0.05)。NS和CRF的血清FT₃ 、FT₄ 和TSH的改变与血清蛋白、尿蛋白均无相关关系。结论： NS和CRF急性期患儿都存在着甲状腺功能指标异常降低，NS恢复期甲状腺功能可恢复正常，提示无需甲状腺激素治疗；而CRF可导致中枢性的甲状腺功能障碍，甲状腺激素治疗有一定价值。

STUDY OF THYROID FUNCTION IN CHILDREN RENAL DISEASE

Zhou Xiang,Peng Rui,Pang Ning,et al 1999；13(1)：11

    (Department of Pediatrics;Department of Endocrinology)

Abstract Objective: Toinvestigate the changes of thyroid hormore(TH) abnormalities in nephrotic syndrome(NS) and chronic renal failure(CRF),the serum free tri-iodothyronine(FT₃ ) and thyroxine(FT₄ ) levels were used to estimate the thyroid function when there is some alteration in serum binding protein of NS and CRF.Methods: We have examined the serum FT₃ ,FT₄ and TSH of children NS(n=8) and CRF(n=7),in comparison with that of two control groups,in remission of NS(RENS=7) and age-matched children(NC=9).Results: In Comparison with two control groups,a significant decrease in FT₄ (P<0.05) and increase in the serum TSH concentration(P<0.05) in NS were observed.The serum FT₃ and FT₄ (P<0.05) concentration were significantly decreased,but the serum TSH was normal(P>0.05) in CRF.The serum FT₃ ......

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