当前位置: 首页 > 期刊 > 《中华心血管病杂志》 > 1999年第2期
编号:10668391
静脉注射依那普利拉治疗重症高血压的疗效及安全性
http://www.100md.com 《中华心血管病杂志》 1999年第2期
依那普利拉|高血压,恶性|治疗结果,关键词:
静脉注射依那普利拉治疗重症高血压的疗效及安全性

     郭冀珍 陆德澄 赵福全 杨菊贤 杜俭 200025 上海第二医科大学附属瑞金医院(郭冀珍、杜俭);镇江医学院附属医院心内科(陆德澄);扬州大学医学院附属医院(赵福全);上海第二医科大学附属第九人民医院(杨菊贤) 中华心血管病杂志 1999 0 27 2


    关键词:依那普利拉;高血压,恶性;治疗结果 期刊 zhxxgbzz 0 临床研究 fur -->


    

摘要 目的 验证国产依那普利拉(E)治疗重症高血压的降压疗效及安全性,以提供高血压急症的新药。方法 对上海、镇江、扬州等4家医院收治的172例高血压病重症患者,男118例,女54例,平均年龄(53±9)岁,静脉注射E。分组:(1)对三组高血压病(各10例)分别静脉注射E1.25 mg、2.5 mg、5 mg;(2)E与甲磺酸酚妥拉明(P)各54例单次静脉注射开放平行比较试验;(3)34例为24小时内多次静脉注射E(q6h),观察24小时内血压、心率及不良反应。结果 结果显示:(1)不同剂量E静脉注射以2.5mg降压效果最好;(2)两组比较:用药后2、4、6小时E组降压幅度优于P组(P<0.05),总有效率为96.3%,P组总有效率90.7%;(3)24小时多次给E,总有效率达100%。E主要不良反应:轻度头昏(6/118)、头痛(2/118)、肢体麻木(4/118)及咳嗽(5/118)。结论 国产E是一种安全有效的治疗高血压急症用药,我们推荐静脉首选剂量2.5mg为宜。

Effect of intravenousenalaprilat on severe essential hypertension GUO Jizhen, LU Decheng* , ZHAO Fuquan** ,et al. Ruijin Hospital and Shanghai 9th Hospital of Shanghai Second Medical University,Shanghai 200025 Zhenjiang Medical College Affillated Hospital, Zhenjiang 212001 ** Yangzhou Medical CollegeAffillated Hospital, Yangzhou 225000

    
Abstract Objective To evaluate the acuteantihypertensive effect and safety of intravenous administration of enalaprilat. Methods 172 patients with severehypertension (DBP 120mm Hg, 118 male, 54 female, mean age 53±9 years old )were admitted to four hospitalswhich are in Shanghai, and Zhenjiang and Yangzhou in Jiangsu province. The study weredivided into three groups: (1) Three different doses of enalaprilat (1.25mg, 2.5mg,5mg)were injected by an intravenous bolus to 10 cases for each group to evaluate theappropriate dosage. (2) A comparison of enalaprilat (2.5mg iv )and phentolamin (5mg iv )in54 for each group of severe hypertension. (3) The antihypertensive effect of continuousbolus injection of enalaprilat every 6 hours to 34 cases in 24 hours. Results (1) The bolus of 2.5 mgenalaprilat is the most appropriate dosage to decrease the severe hypertension. (2) After1-24 hours,the blood pressure decreased significantly in both enalaprilat and phentolamininjection groups (P<0.05), more reductions of systolic blood pressure and distolicblood pressure were seen in enalaprilat group than those in phentolamin group at 4, 6, 8hours respectively (P<0.05). (3) The antihypertensive effective rate was 96.3% in thegroup with bolus injection of 2.5mg enalaprilat, 100% in multitime (q6h) injectionpatients. (4)Slight adverse experiences of enalaprilat during the period of the study aredizziness(6/118), headache (2/118), numbness(4/118) and cough (5/118) included. Conclusion Intravenous enalaprilat(2.5 mg)can be used safely and effectively to control blood pressure in patients with severehypertension.

    
Keywords enalaprilat hypertension, malignant treatment outcome

众所周知 ......


您现在查看是摘要页,全文长 17934 字符