静脉注射依那普利拉治疗重症高血压的疗效及安全性
依那普利拉|高血压,恶性|治疗结果,关键词:
关键词:依那普利拉;高血压,恶性;治疗结果
【摘要 】 目的 验证国产依那普利拉(E)治疗重症高血压的降压疗效及安全性,以提供高血压急症的新药。方法 对上海、镇江、扬州等4家医院收治的172例高血压病重症患者,男118例,女54例,平均年龄(53±9)岁,静脉注射E。分组:(1)对三组高血压病(各10例)分别静脉注射E1.25 mg、2.5 mg、5 mg;(2)E与甲磺酸酚妥拉明(P)各54例单次静脉注射开放平行比较试验;(3)34例为24小时内多次静脉注射E(q6h),观察24小时内血压、心率及不良反应。结果 结果显示:(1)不同剂量E静脉注射以2.5mg降压效果最好;(2)两组比较:用药后2、4、6小时E组降压幅度优于P组(P<0.05),总有效率为96.3%,P组总有效率90.7%;(3)24小时多次给E,总有效率达100%。E主要不良反应:轻度头昏(6/118)、头痛(2/118)、肢体麻木(4/118)及咳嗽(5/118)。结论 国产E是一种安全有效的治疗高血压急症用药,我们推荐静脉首选剂量2.5mg为宜。
Effect of intravenousenalaprilat on severe essential hypertension GUO Jizhen, LU Decheng* , ZHAO Fuquan** ,et al. Ruijin Hospital and Shanghai 9th Hospital of Shanghai Second Medical University,Shanghai 200025 Zhenjiang Medical College Affillated Hospital, Zhenjiang 212001 ** Yangzhou Medical CollegeAffillated Hospital, Yangzhou 225000
【 Abstract 】 Objective To evaluate the acuteantihypertensive effect and safety of intravenous administration of enalaprilat. Methods 172 patients with severehypertension (DBP ≥ 120mm Hg, 118 male, 54 female, mean age 53±9 years old )were admitted to four hospitalswhich are in Shanghai, and Zhenjiang and Yangzhou in Jiangsu province. The study weredivided into three groups: (1) Three different doses of enalaprilat (1.25mg, 2.5mg,5mg)were injected by an intravenous bolus to 10 cases for each group to evaluate theappropriate dosage. (2) A comparison of enalaprilat (2.5mg iv )and phentolamin (5mg iv )in54 for each group of severe hypertension. (3) The antihypertensive effect of continuousbolus injection of enalaprilat every 6 hours to 34 cases in 24 hours. Results (1) The bolus of 2.5 mgenalaprilat is the most appropriate dosage to decrease the severe hypertension. (2) After1-24 hours,the blood pressure decreased significantly in both enalaprilat and phentolamininjection groups (P<0.05), more reductions of systolic blood pressure and distolicblood pressure were seen in enalaprilat group than those in phentolamin group at 4, 6, 8hours respectively (P<0.05). (3) The antihypertensive effective rate was 96.3% in thegroup with bolus injection of 2.5mg enalaprilat, 100% in multitime (q6h) injectionpatients. (4)Slight adverse experiences of enalaprilat during the period of the study aredizziness(6/118), headache (2/118), numbness(4/118) and cough (5/118) included. Conclusion Intravenous enalaprilat(2.5 mg)can be used safely and effectively to control blood pressure in patients with severehypertension.
【 Keywords 】 enalaprilat hypertension, malignant treatment outcome
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