倪泉兴 张群华 蔡端 向阳 侯兰娣 张延龄 200040 上海医科大学华山医院外科 中华实验外科杂志 1999 0 16 3


    关键词：急性坏死性胰腺炎；心；肾；损伤；介质 期刊 zhsywkzz 0 胰腺外科 fur -->


    

【摘要 】 目的 探讨急性坏死性胰腺炎(ANP)对心肾损伤的影响。方法 采用3.5%牛磺胆酸逆行注射胰胆管建立鼠的ANP模型。观察炎性介质内毒素、淀粉酶、磷脂酶A₂ ，白细胞介素(IL-)1、肿瘤坏死因子x(TNFα)的变化和生长抑素的作用。结果 ANP可以诱导炎性介质的明显升高，并与心肾损伤的严重程度呈正相关。而生长抑素能抑制ANP的炎性介质过度表达，减轻心肾损伤的程度。结论 炎性介质参与了ANP对心肾器官的损伤，生长抑素对ANP的心肾损伤有治疗价值。

Heart and kiddney organ damage inexperimental acute necrotizing pancreatitis

NI Quanxing, ZHANG Qunhua, CAI Duan, et al.

    Department of Surgery, Huashan Hospital, Shanghai Medical University, Shanghai 200040

【Abstract 】 Objective To study the heart and kidney organ damage in experimental acute necrotizing pancreatitis (ANP). Methods The roles of inflammatory mediators (endotoxin, amylase,IL-1 β, IL-6,TNFα,PLA2)were investigated in ANP model established by retrogradeinjection of 3.5% sodium taurocholate 2.5 ml/kg into pancreatic duct, and the efficiencyof somatosatin analogene stilamin was also observed. Results ANP couldinduce the obvious increase of the inflammatory mediators which was positively correlatedwith the development of heart and kidney damage. Somatostatin could inhibit theoverexpression of inflamatory mediators and alleviate the risk of heart and kidney organdamage. Conclusions Inflammatory mediators might play an important rolein ANP progression and somatostatin may be the efficient treatment to prevent thedevelopment and progression of heart and kidney damage.

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