摘要 目的：研究碱性成纤维细胞生长因子(bFGF)在人脑胶质瘤的发生发展中的作用。方法：用Northern杂交法检测了人脑胶质瘤组织中的bFGF基因表达，并探讨bFGF基因表达与胶质瘤恶性程度的关系。结果：胶质瘤bFGF基因表达异常升高，57例胶质瘤中的52例可见bFGF基因表达，阳性率为91.2%，而8例正常脑组织则未见表达，随胶质瘤恶性程度增加，bFGF基因表达也升高。结论：bFGF的促细胞增殖和促血管生成作用与胶质瘤的进展可能有密切关系。

Abstract Objective: To study the role of bFGF in the generation anddevelopment of glioma. Methods: The expression of bFGF was detected with Northerm blothybridization in 57 gliomas, and the level of expression was compared with the tumorgrade. Results: The expression of bFGF gene was observed in 52 of 57 gliomas. Theexpression rate was 91.2%, while that was not observed 8 normal brain tissues. The levelof expression of bFGF increased in parallel with the malignant grade of glioma.Conclusion: This indicated that the bFGF as a potent mitogen and angiogenin may play animportant role in the development and progression of glioma.

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