周永列 刘建栋 310014 杭州，浙江省人民医院 中华实验外科杂志 1999 0 16 6


    关键词：前列腺肿瘤；总前列腺特异抗原；游离前列腺特异抗原；癌 期刊 zhsywkzz 0 前列腺外科 fur -->


    

【摘要】 目的 探讨血清游离前列腺特异抗原(fPSA)/总前列腺特异抗原(tPSA)比值对前列腺癌的诊断价值。方法 用酶联双抗夹心法检测22例前列腺癌，48例前列腺增生(BPH)和20例正常对照组的血清fPSA、tPSA，并计算fPSA/tPSA比值，评价其对前列腺癌的诊断价值。结果 以fPSA/tPSA 0.15为判断上限时，其诊断敏感性为90.9%，特异性为87.5%，诊断准确性为88.6%，明显优于tPSA和fPSA单独测定结果。结论 fPSA/tPSA可更有效地诊断前列腺癌。

Clinical implication of fPSA/tPSA in the diagnosis of prostatic cancer

ZHOU Yonglie, LIU Jiandong.

    Zhejiang Provincial People's Hospital, Hangzhou 310014

【Abstract】 Objective To investigate the diagnostic value of free prostate specific antigen (fPSA)/total prostate specific antigen (tPSA) in prostatic cancer. Methods Serum fPSA and tPSA were measured in 22 patients with prostatic carcinoma, 48 benign prostatic hyperplasia and 20 healthy subjects by using enzyme linked immunosorbent assay and the ratio of fPSA/tPSA was calculated. Results When the upper normal limit of fPSA/tPSA was set at 0.15, the diagnostic sensitivity was 90.9 %, the specificity 87.5 % and the accuracy 88.6 %, obviously superior to the results of tPSA or fPSA used alone. Conclusion fPSA/tPSA is more useful as a tumor marker for prostatic cancer.

    【Key words】 Prostatic neoplasm Total prostatic specific antigen Free prostatic specific antigen Cancer

我们用ELISA法检测了22例前列腺癌(PCa)和48例前列腺增生(BPH)病人的血清游离前列腺特异抗原(fPSA)、总前列腺特异抗原(tPSA)及前列腺酸性磷酸酶(PAP) ......

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