摘要 目的：探讨各种颅内生殖细胞肿瘤中免疫组织化学染色的诊断意义。方法：对76例颅内生殖细胞肿瘤进行5种抗体的免疫组织化学染色。结果：胎盘碱性磷酸酶(PLAP)阳性率82%(62/76)，绒毛膜促性腺激素(HCG)阳性率30%(23/76)，胎盘催乳素(HPL)仅占5%(4/76)，甲胎蛋白(AFP)和妊娠特异性β 1糖蛋白(SP₁ )在卵黄囊癌中阳性率100%(5/5)。结论：PLAP可用于生殖细胞肿瘤与其他肿瘤鉴别诊断。AFP和SP₁ 可检出畸胎瘤中不易察觉的卵黄囊癌成分。SP₁ 阳性可能提示肿瘤恶性程度高，预后差。

    Immunohistochemical study of intracranial germ cell tumors Dai Ke, Luo Lin, Yue Shenglin, et al. Beijing Neurosurgical Institute, Beijing 100050

    Abstract Objective: To evaluate the value of immunohistochemical stain in diagnosis for various intracranial germ cell tumors. Methods: 76 cases with intracranical germ cell tumors were studies by immunohistochemical method with five different monoclonal antibodies. Results: The positive rate of placenta alkaline phosphatase (PLAP), human chorionic gonadotropin (HCG) and human placental lactogen (HPL) was 82% (62/76), 30% (23/76) and 5% (4/76) respectively. In yolk sac tumors, the positive rate of alfafetoprotein (AFP) and pregnancy-specific-β 1 glycoprotein (SP₁ ) was 100% (5/5). Conclusion: PLAP can be applied for differentiating diagnosis of germinomas from other tumors. The indistinguishable yolk sac tumors cell in teratomas can be found by AFP staining combined with SP₁ staining. The latter indicate a higher malignant degree.

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