摘要 目的 ：探讨异基因骨髓移植(allo-BMT)后肺部合并症发生的危险因素、发病机制及有效防治方法。方法 ：总结185例allo-BMT患者的肺部合并症资料。结果 ：89例患者发生93例次肺部合并症，病因多为感染，其中细菌性肺炎27例次，间质性肺炎7例次，肺真菌病16例次，肺结核4例次，阻塞性肺病2例次，肺水肿2例次，肺脓疡1例；由2种或2种以上病原所致的肺部合并症34例次。由肺部疾患导致死亡者23例(病死率12.4%)。结论 ：allo-BMT后肺部合并症的发生与受者年龄、性别、BMT前骨髓状态、预处理方法及肺功能均无关；而移植物抗宿主病显著提高BMT后患者肺部合并症的发病率及病死率。

Pulmonary complications occurringafter allogeneic bone marrow transplantation Fan Yunming, Guo Nailan, Huang Xiaojun, et al. The Institute of Hematology, People's Hospital，Beijing Medical University,Beijing 100044

    Abstract Objective:Toexplore the risk factors for and pathogenesis of pulmonary complications (PC) occurredafter allogeneic bone marrow transplantation (allo-BMT). Methods: The PC in 185 patientsundergone allo-BMT were analyzed. Results: Ninty-three PC episodes were observed in 89patients and most of them were due to infections, including bacterial pneumonia (n=27),interstitial pneumonia (n=7), pulmonary fungus disease (n=16), tuberculosis (n=4),obstructive lung disease (n=2), pulmonary edema (n=2), lung abscess (n=1) and 34 episodescaused by two or more pathogens. The overall mortality for PC was 12.43% (23/185).Conclusion: The risk factors for PC occurred after allo-BMT were not related to age andsex of recipients, bone marrow status before BMT, conditioning regimen and pulmonaryfunction. Graft-versus-host-disease significantly increased the morbidity and mortality ofPC after allo-BMT.

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