刘元涛 袁明霞 袁申元 朱良湘 100005 北京，首都医科大学附属北京同仁医院糖尿病微循环科 中华肾脏病杂志 1999 0 15 2


    关键词：黄腐酸钠；糖尿病肾病；组织型纤溶酶原激活剂；纤溶酶原激活剂抑制物 期刊 zhszbzz 0 继发性肾小球疾病专题论著 fur -->


    

【摘要 】 目的 研究黄腐酸钠对糖尿病大鼠肾脏病变的保护作用及其机制。方法 观察黄腐酸钠对肾小球形态，肾小球基底膜超微结构，尿白蛋白排出率的影响及血浆组织型纤溶酶原激活剂(t-PA)、纤溶酶原激活剂抑制物(PAI-1)活性改变。结果 糖尿病大鼠血浆t-PA活性明显降低，而PAI-1活性升高。黄腐酸钠明显降低糖尿病大鼠尿白蛋白，抑制肾小球肥大，延缓肾小球基底膜增厚及足突融合，显著提高血浆t-PA活性而降低PAI-1活性。结论 黄腐酸钠对糖尿病肾病具有保护作用。此作用可能与提高血浆纤溶活性有关。

Protective effect of sodium fulvateon diabetic nephropathy in streptozotocin-induced diabetic rats

LIU Yuantao,YUAN Mingxia,YUANShenyuan,et al.Department of Microcirculation and Diabetes,Capital University of MedicalSciences,Affiliated Beijing Tongren Hospital,Beijing 100005

【Abstract 】 Objective Toevaluate the protective effect of sodium fulvate on diabetic glomerulopathy instreptozotocin-induced diabetic rats and explore its possible mechanism.Methods Changesof indexes,including mean glomerular area,mean glomerular volume,mean glomerular basementmembrane thichness,uninary albumin excretion rate,t-PA and PAI-1 activities,were observed.Results Plasmat-PA activity decreased and PAI-1 activity increased in diabetic rats.Sodium fulvatereduced albuminuria,inhibited glomerular enlargement,delayed the progress of glomerularbasement membrane thickening and reduced foot process fusion.Plasma t-PA activityincreased and PAI-1 activity decreased significantly in sodium fulvate treated diabeticrats.Conclusion Sodium fulvate may help prvenent the development ofdiabetic nephropathy,and this effect may be partly achieved by correcting plasma t-PA andPAI-1 activities.

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