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164例Coombs试验阳性的自身免疫性溶血性贫血的临床研究
http://www.100md.com 《中华血液学杂志》 1998年第11期
贫血,溶血性|自身抗体|环孢霉素A|Coombs试验,关键词:
     张益枝 储榆林 陈桂彬 林泽嬉 邵宗鸿 300020 天津,中国医学科学院、中国协和医科大学血液学研究所、血液病医院 中华血液学杂志 1998 11 19 11


    关键词:贫血,溶血性;自身抗体;环孢霉素A;Coombs试验 期刊 zhxyxzz 0 论 著 fur -->


    

摘要 目的 :研究自身免疫性溶血性贫血(AIHA)的临床特征,进一步指导治疗。方法 :采用回顾性分析患者资料,率的比较采用精确概率法,均值比较采用t检验。结果 :AIHA多发生在女性,继发性占49%,以胶原系统疾病为主,Coombs分型以IgG+C3 型为主,IgG+IgM阳性的患者临床表现最严重,环孢霉素A(CsA)联用皮质激素组有效率为90.9%。结论 :皮质激素仍为治疗AIHA的首选药物,合用CsA可提高疗效,缩短疗程。

    Clinical analysis of 164 cases Coombs test positive autoimmune hemolytic anemia Zhang Yizhi, ChuYulin, Chen Guibin,et al. Institute of Hematology and Blood Diseases Hospital,CAMSand PUMC,Tianjin 300020

    Abstract Objective: To analyze the clinical features and treatmentoutcomes of autoimmune hemolytic anemia (AIHA). Methods: Coombs testpositive AIHA patients were retrospectively analyzed. Results : Patientswith AIHA were predominantly female, secondary AIHA accounted for 49% of the total cases,mainly associated with connective tissue diseases. In most cases of AIHA, the anti-redcell antibodies were IgG plus C3 , while patients with IgG plus IgM had moresevere clinical manifestations. The response rate of adrenocortical hormones andcyclosporin A (CsA) was 90.9%. Conclusion: Adrenocorticosteroids is stillthe first choice of therapy for AIHA,CsA can improve the response rate.

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