外周血干细胞移植,异基因_骨髓移植,异基因

异基因外周血干细胞移植和异基因骨髓移植的临床疗效比较

http://www.100md.com 《中华血液学杂志》 1999年第8期

外周血干细胞移植,异基因|骨髓移植,异基因|移植物抗宿主病,关键词：

     王玫韩明哲冯四洲李成文邱录贵姜容邹德慧阎石杨丛林韩忠朝严文伟天津，中国医学科学院、中国协和医科大学血液学研究所 300020 中华血液学杂志 1999 0 20 8

    关键词：外周血干细胞移植,异基因；骨髓移植,异基因；移植物抗宿主病期刊 zhxyxzz 0 论著 fur -->

【摘要】目的比较异基因外周血干细胞移植(allo-PBSCT)与异基因骨髓移植(allo-BMT)的临床疗效。方法用alloBMT治疗26例;用allo-PBSCT治疗24例。预处理方案包括环磷酰胺(CY)120mg/kg+单次全身照射(STBI)9～10Gy或马利兰(BU)16mg/kg或马法兰(Mel)140～160mg/m²+CY120mg/kg。结果 PBSCT组造血重建23例，中位随访时间352(19～745)天，移植相关死亡4例(16.7%)，2年无病生存率(67.9±11.3)%,复发3例(12.5%)；而BMT组造血重建24例，中位随访时间546(19～2329)天,移植相关死亡7例(26.9%)，2年无病生存率(57.7±9.7)%,复发5例(19.2%)。两组差异不明显。发生aGVHDPBSCT组6例(25%)，BMT组6例(23.1%)，两组比较,差异无显著性(P=0.624)，但PBSCT组发生cGVHD13例(56.5%)明显高于BMT组的1例(3.85%)(P=0.0002)。结论 allo-PBSCT疗效与allo-BMT相当，但要注意防治cGVHD。

Comparison of clinical outcome betweenallogeneic peripheral blood stem cell transplantation and bone marrow transplantation

WANG Mei, HAN Mingzhe, FENG Sizhou, et al.Instituteof Hematology, CAMS and PUMC, Tianjin 300020

【Abstract 】Objective Tocompare the clinical outcome of allogeneic peripheral blood stem cell transplantation(PBSCT) witd that of bone marrow transplantation(BMT). Methods Twenty-sixpatients received allo-BMT and 24 received allo-PBSCT in our hospital between August1991 and September 1998. Conditioning regimens were CY 120 mg/kg plus STBI 9～10 Gy or BU16 mg/kg or Mel 140～ 160 mg/m² plus CY 120 mg/kg .Results Twenty-threepatients of PBSCT and 24 of BMT group engrafted successfully. The median follow-upduration was 352(19～ 745)days for the PBSCT group and 546(19～ 2 329) days for the BMTgroup. Transplant-related deatd was 4(16.7%)patients in the PBSCT and 7(26.9%) inBMT group (P=0.38). Three(12.5%) patients in PBSCT and 5(19.2%) in BMT group relapsed(P=0.27). The 2-year probabilities of disease-free survival(DFS) for PBSCT andBMT group were (67.9± 11.3)% and (57.7± 9.7)% , respectively(P=0.24). aGVHD occurredin 6(25%) patients in the PBSCT and 6(23.1%) in the BMT group (P=0.624), while cGVHDdid in 13(56.5%) and 1 (3.85%), respectively(P=0.0002).Conclusion Theclinical outcome of allo PBSCT is similar to allo-BMT, except for a higher incidenceof cGVHD.

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