刘代红 郭乃榄 张耀臣 许兰平 陈欢 黄晓军 范韫明 刘开彦 王晓红 陆道培 [刘代红、郭乃榄、张耀臣、许兰平、陈欢、黄晓军、范韫明、刘开彦、王晓红(现在北京朝阳市中心医院工作)、陆道培]北京医科大学血液病研究所 100044 中华血液学杂志 1999 0 20 8


    关键词：骨髓移植，异基因白；血病，髓系，慢性；预处理方案复发 期刊 zhxyxzz 0 论著 fur -->


    

【摘要 】目的 分析异基因骨髓移植治疗慢性髓系白血病患者长期存活的影响因素。方法采用TBI或改良BU/CY预处理方案进行异基因骨髓移植,治疗慢性髓系白血病。118例患者中慢性期91例，加速期19例，急变期2例，第2次以上慢性期6例。结果109例植活。慢性期和加速期患者的5年存活概率分别为69.6%和51.0%；5年复发概率分别为3.2%和12.5%。结论病期、预处理方案和脾大对植活时间无影响，慢性期患者脾大与复发呈正相关；两种预处理方案对慢性期患者移植效果的影响，差异无显著性。

Allogeneic bone marrow transplantation forchronic myeloid leukemia:118 cases analysis

LIU Daihong, GUO Nailan, ZHANG Yaochen, et al.Institute of Hematology, Beijing Medical University, Beijing 100044

【Abstract 】 Objective Toanalyze the outcome of allogeneic bone marrow transplantation (allo-BMT) performed forchronic myeloid leukemia (CML) patients. Methods One hundred andeighteen CML patients received allo-BMT witd conditioning regimens of TBI or modifiedBU/CY. The pre-BMT situations were, 91 cases in first chronic phase (CP₁ ), 19in accelerating phase (AP), 2 in blast crisis (BC) and 6 in advanced CP (>CP₂ ).Results One hundred and nine patients were successfully engrafted. Theprobabilities of 5 year suvival for CP1 and AP patients were 69.6% and 51.0% , and 5year relapse rates were 3.2% and 12.5% , respectively. Conclusions Diseasestage, conditioning regimen and splenomegaly did not affect the time for engraftment. Forpatients in CP1 ......