麦炜颐 叶任高 马虹 何小洪 曾群英 冯冲 李玉杰 王礼春 陈国伟 曾志杰 510080 广州，中山医科大学附属第一医院内科 中华肾脏病杂志 1999 0 15 2


    关键词：高血压；镁/代谢；离子交换 期刊 zhszbzz 0 论著 fur -->


    

【摘要 】 目的 探讨原发性高血压(EH)、肾实质性高血压(RH)和肾血管性高血压(RVH)患者红细胞镁含量(EMC)、Mg²⁺ /Na⁺ 交换速率(V_NDmax )及其与血压的关系。方法 原子吸收光谱火焰法。结果 (1)EH组的EMC[(2.03±0.06)mmol/L]显著较正常对照组(2.16±0.04)、RH(2.17±0.05)和RVH(2.15±0.04)组低，而V_NDmax [(155.3±15.2)μmol^. L^-1. h^-1 ]显著较另外三组高(分别为96.8±13.2、94.3±14.2和97.3±12.5)。(2)EH组V_NDmax 与舒张压显著相关(r=0.4872，P<0.05)。结论 (1)EH患者V_NDmax 明显升高，是造成EMC低下的原因，可能在疾病的发生发展中起一定作用。(2)RH、RVH患者细胞镁代谢状况无异常。

Study of erythrocyte magnesiumcontent and Mg²⁺ /Na⁺ exchange rate in patients with hypertension

MAI Weiyi, YE Rengao, MA Hong, et al.Department of Internal Medicine, First Affiliated Hospital, Sun Yat-sen University ofMedical Sciences, Guangzhou 510080

【Abstract 】 Objective Toinvestigate the erythrocyte magnesium content (EMC), magnesium-sodium exchange rate (V_NDmax )and its relationship with blood pressure in patients with essential hypertension (EH),renal parenchymal hypertension(RH) and renal vascular hypertension(RVH). Methods EMC and V_NDmax were measured by flame assay of atomic absorptionspectrophotometry. Results (1) EMC in EH group [(2.03±0.06)mmol/L]was significantly lower than normal control(2.16±0.04), RH(2.17±0.05) and RVH(2.15±0.04)group, while V_NDmax [(155.3±15.2)μmol^. L^-1. h^-1 ]wassignificantly higher than other three groups (96.8±13.2, 94.3±14.2 and 97.3±12.5respectively).(2) V_NDmax in EH group closely correlated to diastolic blood pressure(r=0.4872, P<0.05). Conclusion (1)V_NDmax increases inEH,which is the cause of low EMC and might contribute to the pathogenesis of the disease.(2) cellular magnesium metabolism is not abnormal in RH and RVH.

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