摘要 目的 :探讨血清中细胞因子变化在恶性淋巴瘤(ML)中的意义。方法 :采用放射免疫分析法及酶联免疫吸附法测定了49例ML患者血清中白细胞介素2(IL-2)等5种细胞因子浓度。结果 :除肿瘤坏死因子α(TNFα)外,大部分初治、复发患者中治疗前IL-2,可溶性白细胞介素2受体(sIL-2R),IL-6,IL-8升高;治疗有反应的下降,完全缓解时与对照组无差异;治疗无反应的仍保持高水平。IL-2及sIL-2R升高与患者的临床分期有关,Ⅲ、Ⅳ期患者较Ⅰ、Ⅱ期明显增高;sIL-2R与肿瘤负荷有关;IL-6与患者有无B组症状相关,B组患者明显高于A组,而与分期无关;IL-8升高与临床分期及B组症状有关,与其他临床血液学指标无关。结论 :细胞因子的变化可以作为观察ML病情及监测治疗反应的一种手段。

    Measurement of five cytokines in the serum ofmalignant lymphoma patients ZhuHongli,Wang Yuezeng,Han Xiaoping,et al.Department of Hematology, General Hospital ofPLA,Beijing 100853

     Abstract Objective: To study the clinical significance of serumcytokine levels in patients with malignant lymphoma(ML).Methods: Serumlevels of five cytokines and receptor were measured in 49 patients with ML by RIA andELISA.Results: Except TNFα,significantlyhigher pretreatment levels of interleukin-2(IL-2),soluble interleukin-2 receptor(sIL-2R),interleukin-6(IL-6) and interleukin-8(IL-8) were observed in most of ML patients atdiagnosis or relapse as compared with controls(P<0.05).Cytokine levels declined in responding patients after therapy and there were nodifferences between CR cases and controls,the cytokine levels remained elevated innon-responding patients. The levels of IL-2 and sIL-2R correlated with the clinical stage, which were significantly higher in patients in stage Ⅲ、Ⅳ.The increase of sIL-2R correlated with the tumor burden.The levelof IL-6 was higher in patients presenting B symptoms and had no correlation with theclinical stage.The elevated IL-8 level correlated with the clinical stage and presenting Bsymptoms of ML patients and had no correlation with other clinical-hematologicalparameters.Conclusion :The changes of cytokines may be served as a meansto observe the condition of ML patients and supervise their response to treatment.

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