摘要 目的： 探讨p170和p26两种膜蛋白在临床耐药中的作用及相互关系。方法： 用流式细胞仪技术检测了39例急性白血病患者骨髓细胞的p170和p26表达率。结果: 两者在初治敏感组分别为15.89%±4.41%和17.32%±10.20%，在难治复发组分别为31.02%±14.33%和33.78%±15.97%，两组差别均有显著性(P均<0.05)，p170与p26的相关性,r=-0.1578,P>0.5。结论: 两者均与临床多药耐药相关，但它们之间无明显相关性,揭示其耐药机制不同。

    The correlation between p170,p26 and multidrugresistance in refractory/relapse acute leukemia Gao Xiuhua,Zhang Xiaohui,Qiao Zhenhua,et al.Institute ofHematology,Shanxi Medical University,Taiyuan 030001

     Abstract Objective: To explore the role of two membraneproteins,p170 and p26,in clinical drug resistance and their correlation. Methods: The expression of p170 and p26 in bone marrow cells from 39 acute leukemia patients weredetected by flow cytometry. Results: The expression ratios of p170 andp26 were 15.89%±4.41% and 17.32%±10.20%, respectively, in previously untreated group,and 31.02%±14.33% and 33.78%±15.97%, respectively, in refractory/relapse group. Thedifference between the two groups was significant, while there were no correlation betweenp170 and p26 ( r=-0.1578, P>0.5).Conclusion: Bothp170 and p26 were related to clinical multidrug resistance,but the mechanisms weredifferent.

     ......